860526P

1-O-Acyl-Ceramide

Avanti Research^™ - A Croda Brand 860526P, powder

• Synonym(e): 1-oleoyl-N-heptadecanoyl-D-erythro-sphingosine
• Empirische Formel (Hill-System): C₅₃H₁₀₁NO₄
• CAS-Nummer: 1246303-19-4
• Molekulargewicht: 816.37
• UNSPSC-Code: 12352211
• NACRES: NA.25

Eigenschaften

• Form: powder
• Verpackung: pkg of 1 × 5 mg (860526P-5mg)
• Hersteller/Markenname: Avanti Research^™ - A Croda Brand 860526P
• Lipid-Typ: sphingolipids
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• SMILES String: [H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O
• InChI: 1S/C53H101NO4/c1-4-7-10-13-16-19-22-25-27-30-33-36-39-42-45-48-53(57)58-49-50(51(55)46-43-40-37-34-31-28-24-21-18-15-12-9-6-3)54-52(56)47-44-41-38-35-32-29-26-23-20-17-14-11-8-5-2/h25,27,43,46,50-51,55H,4-24,26,28-42,44-45,47-49H2,1-3H3,(H,54,56)/b27-25-,
• InChIKey: FRBOSLBQGQIWQM-YXQBTRHCSA-N

Beschreibung

Allgemeine Beschreibung

1-O-Acyl-Ceramide is an epidermal ceramide present in mouse and human epidermis. It comprises long chain fatty acids in 1-O-position and is synthesized in the endoplasmic reticulum-related sites.

Anwendung

1-O-Acyl-Ceramide is suitable for use as a lipid standard in

• high performance thin layer chromatography (HPTLC)
• in mass and nuclear magnetic resonance spectroscopy for the quantification of lipids isolated from vernix caseosa skin cream
• in liquid chromatography-tandem mass spectrometry for the quantification of 1-O-Acyl ceramides from liver samples

Biochem./physiol. Wirkung

1-O-Acyl-Ceramide functions in maintaining water barrier homeostasis. Deficiency of the glucosylceramide synthase enzyme leads to the accumulation of O-acylceramides. Treatment of human monoclonal antibody, REMD 2.59 leads to the accumulation of 1-O-acyl-ceramides in soleus muscle and depletion in liver.

Verpackung

5 mL Amber Glass Screw Cap Vial (860526P-5mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3