700092P
Avanti
campesterol-d6
campesterol-d6, powder
Synonym(e):
26,27-hexadeuteriocampest-5-en-3β-ol; 111018
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About This Item
Empfohlene Produkte
Assay
>99% (TLC)
Form
powder
Verpackung
pkg of 1 × 1 mg (700092P-1mg)
Hersteller/Markenname
Avanti Research™ - A Croda Brand 700092P
Versandbedingung
dry ice
Lagertemp.
−20°C
Allgemeine Beschreibung
Campesterol-d6 is the deuterated form of campesterol. It is a plant sterol, which is an analog of cholesterol and a brassinosteroid (BR) precursor. The enzyme diminute/dwarf1 mediates the synthesis of campesterol from 24-methylenecholesterol. Campesterol possesses methyl group at C-24 position of the side chain in the cholesterol structure. It is not synthesized in mammanls and is diet derived
Anwendung
Campesterol-d6 has been used as a deuterium-labeled internal standard in gas chromatography (GC)–triple quadrupole mass spectrometry and liquid chromatography-high resolution mass spectrometry (LC-HRMS).
Biochem./physiol. Wirkung
Campesterol reduces the levels of chylomicron. The d6-campesterol along with d6-sitosterol and d6-cholesterol has been used in the transport blood-brain barrier studies in human brain endothelial hCMEC/D3 monolayer cells. Campesterol is a biomarker for tracking cholesterol synthesis and absorption. Campesterol like cholesterol is catabolized by intestinal microbes. It possess chemopreventive functionality prostate and breast tumors. Campesterol also has antiangiogenic property and may be useful in treating disorders related to angiogenesis.
Verpackung
5 mL Amber Glass Screw Cap Vial (700092P-1mg)
Rechtliche Hinweise
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Analysenzertifikate (COA)
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Clinical chemistry, 58(11), 1557-1564 (2012-09-22)
Cholesterol precursors and plant sterols have considerable potential as plasma biomarkers in several disorders of sterol metabolism and intestinal sterol absorption. Oxysterols are associated with atherogenesis, neurodegeneration, and inflammation. We developed a GC-MS method for the simultaneous analysis of these
Phytotherapy research : PTR, 21(10), 954-959 (2007-07-03)
Campesterol, a plant sterol in nature, is known to have cholesterol lowering and anticarcinogenic effects. Since angiogenesis is essential for cancer, it was surmised that an antiangiogenic effect may be involved in the anticancer action of this compound. This study
Clinica chimica acta; international journal of clinical chemistry, 430, 43-47 (2014-01-08)
The analysis of blood for β-sitosterol and campesterol is the measures of cholesterol absorption while lathosterol is a measure of cholesterol synthesis. The biological variability of β-sitosterol, campesterol, and lathosterol was measured using liquid-chromatography tandem mass spectrometry from a cohort
Atherosclerosis, 203(1), 18-31 (2008-08-12)
Plant sterols and stanols (phytosterols/phytostanols) are known to reduce serum low-density lipoprotein (LDL)-cholesterol level, and food products containing these plant compounds are widely used as a therapeutic dietary option to reduce plasma cholesterol and atherosclerotic risk. The cholesterol-lowering action of
Journal of lipid research, 44(3), 533-538 (2003-02-04)
The recent identification of the aberrant transport proteins ABCG5 and ABCG8 resulting in sitosterolemia suggests that intestinal uptake of cholesterol is an unselective process, and that discrimination between cholesterol and plant sterols takes place at the level of sterol efflux
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