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Bernsteinsäuredihydrazid
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Qualitätsniveau
Assay
96%
mp (Schmelzpunkt)
170-171 °C (lit.)
SMILES String
NNC(=O)CCC(=O)NN
InChI
1S/C4H10N4O2/c5-7-3(9)1-2-4(10)8-6/h1-2,5-6H2,(H,7,9)(H,8,10)
InChIKey
HCOMFAYPHBFMKU-UHFFFAOYSA-N
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Nucleosides, nucleotides & nucleic acids, 30(7-8), 577-584 (2011-09-06)
An efficient method for the synthesis of DNA or RNA oligonucleotide 2'-hydrazides is described. Fully deprotected oligonucleotides containing a hydrazide group at the 2'-position of a uridine residue were obtained by a novel two-step procedure: periodate cleavage of an oligonucleotide
Bioorganicheskaia khimiia, 15(10), 1341-1345 (1989-10-01)
A two-step chemical method of introduction of nonradioactive labels in DNA was proposed. At first step DNA is modified by succinic dihydrazide at pH 5.0 and 95 degrees C, or at pH 4.5 and 37 degrees C in presence of
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 113, 88-96 (2016-12-23)
This study aimed to assess the biodistribution of antihyperglycemic insulin-loaded alginate/dextran sulfate-based nanoparticles dual coated with chitosan and technetium-99m-albumin (
Analytical biochemistry, 277(1), 127-134 (1999-12-28)
We developed a convenient method for the synthesis of dextran-based multivalent probes containing N-linked oligosaccharides which is efficient even in a small scale. Oligosaccharides were derivatized with succinic dihydrazide and dimethylamine borane under a mild acidic condition. The derivatized oligosaccharides
Molecular cell, 71(5), 703-717 (2018-08-14)
In amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD), cytoplasmic aggregates of hyperphosphorylated TDP-43 accumulate and colocalize with some stress granule components, but how pathological TDP-43 aggregation is nucleated remains unknown. In Drosophila, we establish that downregulation of tankyrase, a poly(ADP-ribose)
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