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SPhos Pd G6 acylation
≥95%
Synonym(e):
(SPhos)Pd(4-CH2CH2CONHSPh)Br
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About This Item
Empirische Formel (Hill-System):
C39H47BrNO6PPd
CAS-Nummer:
Molekulargewicht:
843.09
MDL-Nummer:
UNSPSC-Code:
12352100
NACRES:
NA.21
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Qualitätsniveau
Assay
≥95%
Form
powder
Eignung der Reaktion
reagent type: catalyst
reaction type: Cross Couplings
Anwendung
SPhos Pd G6 acylation is an oxidative addition complex (OAC) of SPhos for use in bioconjugation. The pendant NHS-functional group allows coupling to protein amines through a selective acylation. The protein-OAC can then be reacted with a second, cysteine-containing protein. This facile approach allows for protein homodimerization as well as the formation of antibody-protein conjugates.
Learn more about G6 Buchwald precatalysts
Learn more about G6 Buchwald precatalysts
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WGK
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Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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Heemal H Dhanjee et al.
Journal of the American Chemical Society, 142(51), 21237-21242 (2020-12-16)
Palladium oxidative addition complexes (OACs) are traditionally accessed by treating an aryl halide-containing substrate with a palladium(0) source. Here, a new strategy to selectively prepare stable OACs from amino groups on native proteins is presented. The approach relies on an
Muhammad Jbara et al.
Angewandte Chemie (International ed. in English), 60(21), 12109-12115 (2021-03-18)
Organometallic reagents enable practical strategies for bioconjugation. Innovations in the design of water-soluble ligands and the enhancement of reaction rates have allowed for chemoselective cross-coupling reactions of peptides and proteins to be carried out in water. There are currently no
Ryan P King et al.
Organic letters, 23(20), 7927-7932 (2021-10-07)
The utilization of isolated Palladium Oxidative Addition Complexes (OACs) has had a significant impact on Pd-catalyzed and Pd-mediated cross-coupling reactions. Despite their importance, widespread utility of OACs has been limited by the instability of their precursor complexes. Herein, we report
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