930466

HMP-alkyne

≥95%

• Synonym(e): 4-Hydroxy-3-(hydroxymethyl)-N-(prop-2-yn-1-yl)benzenesulfonamide
• Empirische Formel (Hill-System): C₁₀H₁₁NO₄S
• Molekulargewicht: 241.26
• MDL-Nummer: MFCD34704580
• UNSPSC-Code: 12352101
• NACRES: NA.22

Eigenschaften

• Beschreibung: Application: Chemoproteomics
• Qualitätsniveau: 100
• Assay: ≥95%
• Form: powder or chunks
• Lagertemp.: −20°C
• SMILES String: OCC1=C(O)C=CC(S(NCC#C)(=O)=O)=C1
• InChI: 1S/C10H11NO4S/c1-2-5-11-16(14,15)9-3-4-10(13)8(6-9)7-12/h1,3-4,6,11-13H,5,7H2
• InChIKey: FINAVIKBDSCNKL-UHFFFAOYSA-N

Beschreibung

Anwendung

HMP-alkyne is a probe that can be used to photochemically label tryptophans. A method was developed using cysteine-reactive compounds including this one to allow for unbiased analysis of proteomic data in quantitative applications (Zanon et al. 2021). The method uses light or heavy labeling with the isotopically labelled desthiobiotin azide (isoDTB) tag for mass spectrometry analysis (Zanon et al. 2020). Analysis then uses the isotopic tandem orthogonal proteolysis activity-based protein profiling (isoTOP-ABPP) workflow (Weerapana et al. 2010, Backus et al. 2016)

Sonstige Hinweise

Profiling the proteome-wide selectivity of diverse electrophiles

A quantitative thiol reactivity profiling platform to analyze redox and electrophile reactive cysteine proteomes

Ethynylation of Cysteine Residues: From Peptides to Proteins in Vitro and in Living Cells

A Chemoproteomic Platform To Assess Bioactivation Potential of Drugs

Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile

Reversibility of Covalent Electrophile-Protein Adducts and Chemical Toxicity

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable