681059

2-Methyl-6-Nitrobenzoesäureanhydrid

97%

• Synonym(e): MNBA
• Empirische Formel (Hill-System): C₁₆H₁₂N₂O₇
• CAS-Nummer: 434935-69-0
• Molekulargewicht: 344.28
• MDL-Nummer: MFCD06797117
• UNSPSC-Code: 12352108
• PubChem Substanz-ID: 24885612
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 200
• Assay: 97%
• Form: solid
• mp (Schmelzpunkt): 173-177 °C
• Funktionelle Gruppe: anhydride; ester; nitro
• SMILES String: Cc1cccc(c1C(=O)OC(=O)c2c(C)cccc2[N+]([O-])=O)[N+]([O-])=O
• InChI: 1S/C16H12N2O7/c1-9-5-3-7-11(17(21)22)13(9)15(19)25-16(20)14-10(2)6-4-8-12(14)18(23)24/h3-8H,1-2H3
• InChIKey: YEKPNMQQSPHKBP-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

2-Methyl-6-nitrobenzoic anhydride is a reagent employed as a coupling promoter in the synthesis of amides, lactones, esters, and peptides.

Anwendung

2-Methyl-6-nitrobenzoic anhydride can be used:

• As a versatile lactonization reagent applicable in the preparation of varieties of macrolide natural products and lactones.
• As a reaction promoter in the synthesis of carboxamide derivatives by using corresponding amines and carboxylic acids.
• In the total synthesis of GRP78 inhibitor prunustatin A, antifungal compound (3R,16E,20E,23R)-(−)-eushearilide and an antiobestic drug tetrahydrolipstatin.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves