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361275

Sigma-Aldrich

3′-Desoxy-3′-fluorthymidin

97%

Synonym(e):

3′-Fluoro-2′,3′-dideoxythymidine, 3′-Fluorodeoxythymidine

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About This Item

Empirische Formel (Hill-System):
C10H13FN2O4
CAS-Nummer:
25526-93-6
Molekulargewicht:
244.22
MDL-Nummer:
MFCD00056058
UNSPSC-Code:
41106305
PubChem Substanz-ID:
24862180
NACRES:
NA.22

Qualitätsniveau

100

Assay

97%

Form

solid

mp (Schmelzpunkt)

176-178 °C (lit.)

Lagertemp.

2-8°C

SMILES String

CC1=CN([C@H]2C[C@H](F)[C@@H](CO)O2)C(=O)NC1=O

InChI

1S/C10H13FN2O4/c1-5-3-13(10(16)12-9(5)15)8-2-6(11)7(4-14)17-8/h3,6-8,14H,2,4H2,1H3,(H,12,15,16)/t6-,7+,8+/m0/s1

InChIKey

UXCAQJAQSWSNPQ-XLPZGREQSA-N

Angaben zum Gen

human ... TK2(7084)

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Anwendung

Promising antiviral agent possessing activity similar to other 3′-deoxy-3′-substituted thymidines.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
MKBK2943V
MKBP5711V
MKBK2943
MKBG8853
MKBD7669

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P Herdewijn et al.
Journal of medicinal chemistry, 30(8), 1270-1278 (1987-08-01)
A series of 2',3'-unsaturated and 3'-substituted 2',3'-dideoxynucleoside analogues of purines and pyrimidines have been synthesized and evaluated for their inhibitory activity against human immunodeficiency virus (HIV). The 2',3'-unsaturated analogues of 2',3'-dideoxycytidine (ddeCyd) and 2',3'-dideoxythymidine (ddeThd), 3'-azido-2',3'-dideoxythymidine (AzddThd), 3'-fluoro-2',3'-dideoxythymidine, 2',3'-dideoxycytidine (ddCyd)
Dan J Kadrmas et al.
Physics in medicine and biology, 58(3), 429-449 (2013-01-09)
Rapid multi-tracer PET aims to image two or more tracers in a single scan, simultaneously characterizing multiple aspects of physiology and function without the need for repeat imaging visits. Using dynamic imaging with staggered injections, constraints on the kinetic behavior
Sébastien Thureau et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 54(9), 1543-1550 (2013-08-07)
As the preparation phase of a multicenter clinical trial using (18)F-fluoro-2-deoxy-d-glucose ((18)F-FDG), (18)F-fluoromisonidazole ((18)F-FMISO), and 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) in non-small cell lung cancer (NSCLC) patients, we investigated whether 18 nuclear medicine centers would score tracer uptake intensity similarly and define hypoxic
Julian L Goggi et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 54(9), 1630-1636 (2013-08-03)
Successful antiangiogenic therapies have been developed for the treatment of various cancers, but not all patients respond. Therefore, the early determination of therapy efficacy is essential for patient management. This study was done to evaluate the utility of various PET
Yuka Yamamoto et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 53(12), 1911-1915 (2012-10-20)
We evaluated 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) uptake in patients with newly diagnosed and recurrent gliomas and correlated the results with tumor grade and proliferative activity. (18)F-FLT PET was investigated retrospectively in 56 patients, including 36 with newly diagnosed gliomas and 20 with
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