165336

Methylborsäure

97%

• Synonym(e): Methanboronsäure
• Lineare Formel: CH₃B(OH)₂
• CAS-Nummer: 13061-96-6
• Molekulargewicht: 59.86
• Beilstein: 1731087
• MDL-Nummer: MFCD00002105
• UNSPSC-Code: 12352103
• PubChem Substanz-ID: 24850133
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 100
• Assay: 97%
• Form: solid
• mp (Schmelzpunkt): 91-94 °C (lit.)
• SMILES String: CB(O)O
• InChI: 1S/CH5BO2/c1-2(3)4/h3-4H,1H3
• InChIKey: KTMKRRPZPWUYKK-UHFFFAOYSA-N

Beschreibung

Anwendung

Methylboronic acid can be used as a reagent:

• In the palladium-catalyzed Stille and Suzuki-Miyaura cross-couplings.
• In the microwave-heated heterogeneous palladium (Pd)-catalytized reactions.
• In ruthenium (Ru)-catalyzed silylation reactions
• To prepare bis(aminotropone) titanium (Ti) catalysts for ethylene polymerizations.
• In the enantioselective asymmetric bromoaminocyclization and bromoaminocyclization using amino-thiocarbamate catalysts.
• To prepare common building blocks for pharmaceuticals and agrochemicals.
• To prepare chrysin analogs by Suzuki-Miyaura coupling reactions.
• To prepare casein kinase I inhibitors.
• In the divergent C-H functionalizations directed by sulfonamide pharmacophores in drug discovery.
• In the synthesis of unsymmetrical monosulfides from disulfides via copper-catalyzed coupling with boronic acids.
• In a palladium-catalyzed coupling with enol tosylates.
• For derivatizing many carbohydrates and biologically active compounds for GLC analysis.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves