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Wichtige Dokumente
116238
5,7-Dimethoxycumarin
98%
Synonym(e):
Citropten, Limettin
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Alle Fotos(2)
About This Item
Empfohlene Produkte
Qualitätsniveau
Assay
98%
Form
solid
mp (Schmelzpunkt)
146-149 °C (lit.)
Funktionelle Gruppe
ester
SMILES String
COc1cc(OC)c2C=CC(=O)Oc2c1
InChI
1S/C11H10O4/c1-13-7-5-9(14-2)8-3-4-11(12)15-10(8)6-7/h3-6H,1-2H3
InChIKey
NXJCRELRQHZBQA-UHFFFAOYSA-N
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Allgemeine Beschreibung
5,7-dimethoxycoumarin is isolated and identified from leaves and fruits of Pelea anisata H. Mann, a plant whose fruit are used in the construction of mohikana leis. It induces frameshift mutagenesis in bacteria. It also causes lethal photosensitization and the formation of sister chromatid exchanges in Chinese hamster cells.
Biochem./physiol. Wirkung
5,7-Dimethoxycoumarin induces the processes of differentiation and melanogenesis in murine (B16) and human (A375).
Signalwort
Warning
H-Sätze
Gefahreneinstufungen
Acute Tox. 4 Oral
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
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International journal of oncology, 34(6), 1727-1735 (2009-05-09)
In this study, the processes of differentiation and melanogenesis induced by 5,7-dimethoxycoumarin in murine (B16) and human (A375) melanoma cells were investigated. Taking into account the previously demonstrated antiproliferative and differentiation activities of this compound, we examined Ras/Raf/Mek/Erk mitogen-activated protein
Chemical & pharmaceutical bulletin, 50(1), 118-120 (2002-02-05)
A new C-8 prenylated 5,7-dimethoxycoumarin named omphamurrayin was isolated from the leaves of Murraya paniculata var. omphalocarpa, and its structure was established as 5,7-dimethoxy-8-(1-oxo-2-senecioyl-3-methyl-3-butenyl)-2H-1-benzopyran-2-one on the basis of the spectroscopic evidence. The taxonomic status of M. paniculata var. omphalocarpa is
Isolation and characterization of the photoadducts of 5,7-dimethoxycoumarin and adenosine.
Photochemistry and photobiology, 46(2), 305-309 (1987-08-01)
Biochimica et biophysica acta, 740(1), 64-72 (1983-05-20)
The photobinding of 5,7-dimethoxycoumarin to isolated adenovirus-type 2 DNA has been investigated with respect to the influence of the ionic environment, and varying molar ratios of DNA(p): 5,7-dimethoxycoumarin. In particular, the ultraviolet radiation-induced covalent addition of 5,7-dimethoxycoumarin to adenovirus DNA
Skin pharmacology : the official journal of the Skin Pharmacology Society, 5(2), 108-113 (1992-01-01)
It is a general rule that percutaneous absorption is increased when the site of application is occluded. In this study we compared the in vitro permeation profiles of two molecules with different physicochemical properties under occluded versus unoccluded conditions. Human
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