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M2922

Sigma-Aldrich

3-Methyl-6-[3-(trifluoromethyl)phenyl]-1,2,4-triazolo[4,3-b]pyridazine

Synonym(s):

CL 218,872

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About This Item

Empirical Formula (Hill Notation):
C13H9F3N4
CAS Number:
66548-69-4
Molecular Weight:
278.23
MDL number:
MFCD00674912
UNSPSC Code:
12352200
PubChem Substance ID:
24278545

storage temp.

2-8°C

SMILES string

Cc1nnc2ccc(nn12)-c3cccc(c3)C(F)(F)F

Gene Information

human ... BZRAP1(9256) , GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA5(2558) , GABRA6(2559) , GABRG2(2566)

Biochem/physiol Actions

Selective agonist at the BZI benzodiazepine receptor.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Precautionary Statements

P261 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
066H4130

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M C Gravielle et al.
Neuroreport, 6(15), 2013-2016 (1995-10-23)
The developmental time-course of type I and type II benzodiazepine receptors in the chick optic lobe was determined using a triazolopyridazine, CL 218872. At embryonic day 13 most of the binding sites corresponded to type II (98.23%), while type I
A Hendrickson et al.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 12(4), 299-314 (1994-06-01)
The expression of subtypes of the GABA-A/benzodiazepine receptor complex has been studied during pre- and postnatal development of Macaca monkey visual cortex using complementary radioligand and immunocytochemical labeling. Type I benzodiazepine receptors were labeled directly by [3H]zolpidem. Type II receptors
K A Wafford et al.
Molecular pharmacology, 44(2), 437-442 (1993-08-01)
The effect of benzodiazepines on the activity of gamma-aminobutyric acid (GABA)A receptors has been shown to be influenced by different alpha subunits and can also be affected by the presence of different gamma subunits. Previous studies have shown that receptors
T Yakushiji et al.
British journal of pharmacology, 109(3), 819-825 (1993-07-01)
1. The effects of benzodiazepine receptor (BZR) partial agonists, Y-23684 and CL218,872, were compared with its full agonist, diazepam, on gamma-aminobutyric acid (GABA)-induced Cl- current (ICl) in acutely dissociated rat cerebral cortex (CTX), cerebellar Purkinje (CPJ) and spinal ventral horn
D Ruano et al.
European journal of pharmacology, 246(1), 81-87 (1993-06-15)
We have investigated the possible modifications of the pharmacological properties of Type I and Type II benzodiazepine binding sites of the gamma-aminobutyric acidA (GABAA) receptor complex in cortical membranes from 3- and 24-month-old Wistar or Fischer rats. No major changes
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