P8615
Phosphoinositide 3-kinase p110γ human
≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution
Synonym(s):
PI3K p110γ human, Phosphatidylinositol 3-kinase p110γ human
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About This Item
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recombinant
expressed in baculovirus infected insect cells
Quality Level
Assay
≥95% (SDS-PAGE)
form
buffered aqueous glycerol solution
specific activity
~4.5 units/mg protein
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... PIK3CG(5294)
General description
Phosphatidylinositol 3-kinase p110γ /phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit γ (PIK3CG) gene, with 12 exons spanning 43 kb on genomic DNA, is mapped to human chromosome 7q22.3. PIK3CG belongs to the family of genes coding for enzymes that phosphorylate the 3′-hydroxyl of phosphatidylinositol.
Biochem/physiol Actions
PI 3-kinases have been implicated in diverse cellular responses triggered by mammalian cell surface receptors. Inhibits NF-κB, AP-1, and STAT1α mediated gene expression induced by IFN-γ resulting in inhibition of COX-2 and NOS ll (iNOS) expression.
Phosphatidylinositol 3-kinase p110γ is implicated in the development of eosinophilic inflammation. Thus, inhibition of PI3Kγ expression can be considered as a potential therapeutic method for treating eosinophil-related diseases, including asthma. Knockdown of PIK3CG gene inhibits the PI3K-Akt/PKB signaling pathway, which is essential for tumorigenesis and the progression of colorectal cancers. Mutation in the gene is associated with the development of autistic disorder.
PI 3-kinases have been implicated in diverse cellular responses triggered by mammalian cell surface receptors. Inhibits NF-κB, AP-1, and STAT1α mediated gene expression induced by IFN-γ resulting in inhibition of COX-2 and NOS ll (iNOS) expression.
Unit Definition
1 unit will transfer 1 nmol of phosphate/min, using phosphatidylinositol as substrate.
Physical form
Solution in 10 mM HEPES, pH 7.5, 100 mM NaCl, 0.5 mM MgCl2, 50% glycerol.
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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The effect of pharmacological PI3Kγ inhibitor on eotaxin-induced human eosinophil functions.
Saito Y, et al.
Pulmonary Pharmacology & Therapeutics, 27, 164-169 (2014)
Association of INPP1, PIK3CG, and TSC2 gene variants with autistic disorder: implications for phosphatidylinositol signalling in autism
Serajee FJ, et al.
Journal of medical Genetics, 40 (2003)
Genome-wide meta-analyses identifies 7 loci associated with platelet aggregation in response to agonists
Johnson AD, et al.
Nature Genetics, 42, 608-613 (2010)
Down-Regulation of PIK3CG, a Catalytic Subunit of Phosphatidylinositol 3-OH Kinase, by CpG Hypermethylation in Human Colorectal Carcinoma
Semba S, et al.
Clinical Cancer Research, 8, 3824-3831 (2002)
B Stoyanov et al.
Science (New York, N.Y.), 269(5224), 690-693 (1995-08-04)
Phosphoinositide-3 kinase activity is implicated in diverse cellular responses triggered by mammalian cell surface receptors and in the regulation of protein sorting in yeast. Receptors with intrinsic and associated tyrosine kinase activity recruit heterodimeric phosphoinositide-3 kinases that consist of p110
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