Insulin is secreted by the islet β cells in the pancreas. It contains two peptide chains linked by disulfide bridges. The A chain is composed of 21 amino acids and the B chain has 30 amino acids.
Application
Rat/Mouse Insulin ELISA is suitable for measuring and quantifying insulin levels in metabolism and endocrine research. It has been used to determine plasma insulin by enzyme-linked immunosorbent assay. It has also been used to measure the insulin secretion from cells, in vitro.
Biochem/physiol Actions
Insulin is a key hormone that maintains normal blood glucose levels. It mediates cellular glucose uptake, controls carbohydrate, lipid, and protein metabolism, and enhances cell division and growth through its mitogenic effects. Insulin resistance is a condition of impaired sensitivity to insulin-mediated glucose disposal.
Other Notes
3 hour assay, room temperature 10 μL sample size Research Category: Metabolism Research Sub Category: Obesity/Metabolic Disorders
Disclaimer
For research use only. Not for use in diagnostic procedures.
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Postnatal growth velocity modulates alterations of proteins involved in metabolism and neuronal plasticity in neonatal hypothalamus in rats born with intrauterine growth restriction.
Alexandre-Gouabau, Marie-Cecile F, et al.
The Journal of Nutritional Biochemistry (2011)
How moderate changes in Akt T-loop phosphorylation impact on tumorigenesis and insulin resistance.
Wullschleger S, Sakamoto K, Johnstone L, Duce S, Fleming S, Alessi DR.
Disease models & mechanisms null
Interactions Between Age, Stress and Insulin on Cognition: Implications for Alzheimer's Disease.
Solas M, Aisa B, Mugueta MC, Del R?-o J, Tordera RM, Ram?-rez MJ
Neuropsychopharmacology null
Amadori-glycated phosphatidylethanolamine, a potential marker for hyperglycemia, in streptozotocin-induced diabetic rats.
Sookwong P, Nakagawa K, Fujita I, Shoji N, Miyazawa T.
Lipids null
Hypoxia-induced intrauterine growth restriction increases the susceptibility of rats to high-fat diet-induced metabolic syndrome.
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