A2487

Cotrimoxazole, Ready Made Solution

100 mg/mL in DMSO

• Synonym(s): Trimethoprim-Sulfamethoxazole, TMP-SMX
• Empirical Formula (Hill Notation): C₁₄H₁₈N₄O₃ · 5 C₁₀H₁₁N₃O₃S
• CAS Number: 8064-90-2
• Molecular Weight: 1556.71
• UNSPSC Code: 51102829
• NACRES: NA.85

Properties

• form: liquid
• Quality Level: 200
• concentration: 100 mg/mL in DMSO
• color: colorless to faint yellow
• antibiotic activity spectrum: Gram-negative bacteria; Gram-positive bacteria; fungi; parasites
• Mode of action: DNA synthesis | interferes
• shipped in: dry ice
• storage temp.: −20°C
• InChI: 1S/C14H18N4O3.C10H11N3O3S/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2-6H,11H2,1H3,(H,12,13)
• InChI key: WZRJTRPJURQBRM-UHFFFAOYSA-N

Description

Application

Cotrimoxazole has been used as an antimicrobial agent.

Biochem/physiol Actions

Cotrimoxazole, a combination of trimethoprim and sulfamethoxazole, interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to dihydrofolate reductase (DHFR) which inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF), resulting in an antimicrobial effect. Sulfamethoxazole interferes with the synthesis of nucleic acids in sensitive microorganisms by blocking the conversion of p-aminobenzoic acid to the coenzyme dihydrofolic acid. The net effect of these actions is to inhibit thymidine synthesis which prevents bacterial DNA synthesis.

Packaging

1ml

Preparation Note

prepared using a 1:5 mixture of trimethoprim:sulfamethoxazole

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Safety Information

• Pictograms: GHS08
• Signal Word: Warning
• Hazard Statements: H361fd,H412
• Precautionary Statements: P202 - P273 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Aquatic Chronic 3 - Repr. 2
• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable