92131

Trimethoprim

≥99.0% (HPLC)

• Synonym(s): 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine, NSC 106568
• Empirical Formula (Hill Notation): C₁₄H₁₈N₄O₃
• CAS Number: 738-70-5
• Molecular Weight: 290.32
• Beilstein: 625127
• EC Number: 212-006-2
• MDL number: MFCD00036761
• UNSPSC Code: 51285203
• PubChem Substance ID: 57653467
• NACRES: NA.85

Properties

• biological source: synthetic
• Quality Level: 200
• Assay: ≥99.0% (HPLC)
• form: powder
• color: white to light yellow
• mp: ≥199.0 °C
• antibiotic activity spectrum: Gram-negative bacteria; Gram-positive bacteria; mycobacteria
• Mode of action: DNA synthesis | interferes; enzyme | inhibits
• storage temp.: 2-8°C
• SMILES string: COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC
• InChI: 1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)
• InChI key: IEDVJHCEMCRBQM-UHFFFAOYSA-N
• Gene Information: human ... DHFRP1(573971) , KCNH1(3756) ; rat ... Dhfr(24312)

Description

General description

Chemical structure: pyrimidine

Application

Trimethoprim is primarily used as an antibacterial agent. It is used in susceptibility studies of Mycobacterium tuberculosis and mechanism of resistance studies in Haemophilus influenzae .

Primarily used as an antibacterial agent. Dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.

Biochem/physiol Actions

Inhibits the synthesis of tetrahydrofolate by procaryote specific dihydrofolate reductase (DHFR).

Trimethoprim is a dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.

Packaging

1g,5g,25g

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Light sensitive. Store under inert gas. Moisture sensitive. Product is sensitive to light and moisture.

Safety Information

• Pictograms: GHS08,GHS07
• Signal Word: Warning
• Hazard Statements: H302,H361d
• Precautionary Statements: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Hazard Classifications: Acute Tox. 4 Oral - Repr. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves