372382
Sodium bicarbonate-13C
98 atom % 13C, 99% (CP)
Synonym(s):
13C Labeled sodium bicarbonate, Sodium hydrogencarbonate-13C
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About This Item
Linear Formula:
NaH13CO3
CAS Number:
Molecular Weight:
85.00
MDL number:
UNSPSC Code:
51113400
PubChem Substance ID:
NACRES:
NA.12
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isotopic purity
98 atom % 13C
Quality Level
Assay
99% (CP)
mp
>300 °C (lit.)
mass shift
M+1
SMILES string
[Na].O[13C](O)=O
InChI
1S/CH2O3.Na/c2-1(3)4;/h(H2,2,3,4);/q;+1/p-1/i1+1;
InChI key
UIIMBOGNXHQVGW-YTBWXGASSA-M
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General description
Sodium hydrogencarbonate-13C is isotopically enriched compound of sodium bicarbonate.
Application
Sodium bicarbonate-13C can be used:
- As a probe for NMR− and MRI− based pH imaging.
- To predict the reaction mechanism in selective hydrogenation of bicarbonate to formate, catalyzed by a ruthenium(III) complex.
- For 13C labeling of amino acid sample for compound-specific stable isotope analysis (CSIA).
Sodium bicarbonate-13C is used to study the lactate metabolism by using hyperpolarized 13C pH imaging and multiparametric MRI.This reagent can be used as probe in nuclear magnetic resonance spectroscopy studies, which enabled large signal gains for low-toxicity hyperpolarized 13C pH imaging in a phantom and in vivo in a murine model of prostate cancer.
Packaging
This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Quantified pH imaging with hyperpolarized 13 C-bicarbonate
Scholz DJ, et al.
Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 73(6), 2274-2282 (2015)
Ferdia A Gallagher et al.
NMR in biomedicine, 24(8), 1006-1015 (2011-08-04)
pH is a fundamental physiological parameter that is tightly controlled by endogenous buffers. The acid-base balance is altered in many disease states, such as inflammation, ischemia and cancer. Despite the importance of pH, there are currently no routine methods for
D E Korenchan et al.
Chemical communications (Cambridge, England), 52(14), 3030-3033 (2016-01-23)
A hyperpolarization technique using carbonate precursors of biocompatible molecules was found to yield high concentrations of hyperpolarized (13)C bicarbonate in solution. This approach enabled large signal gains for low-toxicity hyperpolarized (13)C pH imaging in a phantom and in vivo in
The influence of hydrolysis and derivatization on the determination of amino acid content and isotopic ratios in dual-labeled (13C, 15N) white clover.
Enggrob KL, et al.
Rapid Communications in Mass Spectrometry, 33(1), 21-30 (2019)
David E Korenchan et al.
Oncotarget, 10(58), 6096-6110 (2019-11-07)
There is an unmet clinical need for new and robust imaging biomarkers to distinguish indolent from aggressive prostate cancer. Hallmarks of aggressive tumors such as a decrease in extracellular pH (pHe) can potentially be used to identify aggressive phenotypes. In
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