SML3539

MS177

≥98% (HPLC)

• Synonym(s): N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(6-(4-(2-(3-(2-((2-(2,6- dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4- yl)amino)ethoxy)propanamido)ethyl)piperazin-1-yl)pyridin-3-yl)-1-isopropyl-1H- indazole-4-carboxamide
• Empirical Formula (Hill Notation): C₄₈H₅₅N₁₁O₈
• CAS Number: 2225938-86-1
• Molecular Weight: 914.02
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear (Warmed)
• storage temp.: 2-8°C
• SMILES string: O=C(NCC1=C(C=C(NC1=O)C)C)C2=CC(C3=CC=C(N=C3)N4CCN(CC4)CCNC(CCOCCNC5=CC=CC(C(N6C(C(N7)=O)CCC7=O)=O)=C5C6=O)=O)=CC8=C2C=NN8C(C)C

Description

Biochem/physiol Actions

Cell penetrant and potent PROTAC degrader of EZH2 that effectively depletes both canonical EZH2–PRC2 and noncanonical EZH2–cMyc complexes

MS177 is a cell penetrant and potent PROTAC degrader of EZH2 (enhancer of zeste homologue 2) that effectively depletes both canonical EZH2–PRC2 and noncanonical EZH2–cMyc complexes. MS177 is fast-acting suppressor of cancer growth. MS177 comprises pomalidomide conjugated to a potent EZH2 inhibitor C24 via a short polyethylene glycol linker. It is much more effective and potent in suppressing cancer growth than catalytic inhibitors of EZH2.

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable