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SML3537

CK156

≥98% (HPLC)

Synonym(s):

N-tert-Butyl-7,10-dioxa-13,17,18,21-tetraazatetracyclo[12.5.2.1²,⁶.0¹⁷,²⁰]docosa-1(20),2,4,6(22),14(21),15,18-heptaene-5-carboxamide

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About This Item

Empirical Formula (Hill Notation):
C21H25N5O3
Molecular Weight:
395.45
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

CC(C)(C)NC(C(C=C1)=C(OCCOCCNC2=N3)C=C1C4=C3N(C=C2)N=C4)=O

InChI

1S/C21H25N5O3/c1-21(2,3)25-20(27)15-5-4-14-12-17(15)29-11-10-28-9-7-22-18-6-8-26-19(24-18)16(14)13-23-26/h4-6,8,12-13H,7,9-11H2,1-3H3,(H,22,24)(H,25,27)

InChI key

YCFFONJEHNSECY-UHFFFAOYSA-N

Biochem/physiol Actions

CK156 is a potent and selective DRAK1 inhibitor (IC50 = 49 nM by cell-free radiometric assay, IC50 = 181 nM by cellular NanoBRET, KD = 21 nM by ITC, selectivity by a 468-kinase panel) with good selectivity over DRAK2 (61% inhibition at 1 μM, IC50 = 8 μM by NanoBRET).
Potent and selective DRAK1 (STK17A) inhibitor.

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vibrant-m

C0156

description

≥98% (HPLC)

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≥98% (HPLC)

description

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody

description

NOTE: Both the cell line and DNA from the cell line may be available for this product. Please choose -1VL or VIAL for cells, or -DNA-5UG for DNA.

form

powder

form

powder

form

buffered aqueous glycerol solution

form

-

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

-

assay

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

-

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

-

solubility

-

color

white to beige

color

white to beige

color

-

color

-


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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