SML3361
Imepitoin
≥98% (HPLC)
Synonym(s):
1-(4-Chlorophenyl)-1,5-dihydro-4-(4-morpholinyl)-2H-imidazol-2-one, 1-(4-Chlorophenyl)-4-morpholin-4-yl-5H-imidazol-2-one, AWD 131-138, AWD131-138, ELB138
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About This Item
Empirical Formula (Hill Notation):
C13H14ClN3O2
CAS Number:
Molecular Weight:
279.72
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
eCl@ss:
32039090
Assay:
≥98% (HPLC)
Form:
powder
Pricing and availability is not currently available.
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C1N=C(CN1C2=CC=C(C=C2)Cl)N3CCOCC3
InChI
1S/C13H14ClN3O2/c14-10-1-3-11(4-2-10)17-9-12(15-13(17)18)16-5-7-19-8-6-16/h1-4H,5-9H2
InChI key
IQHYCZKIFIHTAI-UHFFFAOYSA-N
Biochem/physiol Actions
Benzodiazepine-binding site GABAA receptor partial positive allosteric modulator (PAM) with in vivo efficacy in animal models of seizure and epilepsy.
Imepitoin (AWD 131-138; ELB 138) is a g-aminobutyric acid A (GABAA) receptor partial positive allosteric modulator (PAM) that targets the benzodiazepine (BZD)-binding site at the α/γ2-interface. Imepitoin enhances GABA current (% response/[GABA] alone in µM/receptor complex = 320/3/α1β2γ2, 310/25/α1β3γ2, 460/8/α2β2γ2, 590/12/α3β2γ2 and 290/3/α5β2γ2 using Xenopus oocytes expressing respective rat receptor complex) with ~2% the potency and 17-27% the efficacy of diazepam toward α1β2γ2. Imepitoin exhibits in vivo therapeutic efficacy in animal models of seizure and epilepsy.
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This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description - | description - | description May exist as crystalline dimer |
| assay ≥98% (HPLC) | assay - | assay - | assay ≥98.0% (GC) |
| form powder | form - | form - | form crystals |
| Quality Level 100 | Quality Level - | Quality Level - | Quality Level 100 |
| storage temp. 2-8°C | storage temp. - | storage temp. - | storage temp. 2-8°C |
| solubility DMSO: 2 mg/mL, clear | solubility - | solubility - | solubility - |
| color white to beige | color - | color - | color - |
Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Repr. 2
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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