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SML3260

Sigma-Aldrich

Stannsoporfin

≥98% (HPLC)

Synonym(s):

B 992, Dichloro[7,12-diethyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24]-stannate(2-) (OC-6-13)-dihydrogen, SnMP, Stanate, Tin mesoporphyrin

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About This Item

Empirical Formula (Hill Notation):
C34H36Cl2N4O4Sn
CAS Number:
106344-20-1
Molecular Weight:
754.29
UNSPSC Code:
12352200
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

, Faint brown to dark red

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

CC1=C(CCC(O)=O)/C2=C/C3=N/C(C(C)=C3CCC(O)=O)=C\C4=C(CC)C(C)=C(/C=C5N=C(C(C)=C\5CC)/C=C1\N26)N4[Sn]6(Cl)Cl

InChI

1S/C34H38N4O4.2ClH.Sn/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;;/h13-16H,7-12H2,1-6H3,(H4,35,36,37,38,39,40,41,42);2*1H;/q;;;+4/p-4/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;;;

InChI key

LLDZJTIZVZFNCM-UHEVNVKKSA-J

Biochem/physiol Actions

Potent inhibitor of heme oxygenase 1 (HO-1) and heme oxygenase 2 (HO-2)
Stannsoporfin is a potent inhibitor of heme oxygenase 1 (HO-1) and heme oxygenase 2 (HO-2). It inhibits hepatic HO and controls serum levels of bilirubin in infants. Stannsoporfin potently inhibits myeloid HO-1 in tumors. It inhibits immune suppression of chemotherapy-elicited CD8+ T cells. Stannsoporfin concurrently administer with 5-Fluoro uracil produces immediate tumor regression in mice model of breast tumor.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000214559
0000162518
0000177143
0000177142

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Yoshiro Onoue et al.
Circulation journal : official journal of the Japanese Circulation Society, 82(11), 2905-2912 (2018-08-14)
Resistance exercise has beneficial effects for patients with peripheral arterial diseases. The hypothesis that muscle growth promotes angiogenesis by interacting with neighboring cells in ischemic lesions was assessed. Methods and Results: Skeletal muscle-specific inducible Akt1 transgenic (Akt1-TG) mice that induce growth of
Jatin Tulsulkar et al.
Brain research, 1662, 1-6 (2017-02-22)
A gender difference in stroke is observed throughout epidemiologic studies, pathophysiology, treatment and outcomes. We investigated the neuroprotective role of hemeoxygenase (HO) enzyme, which catabolizes free heme to bilirubin, carbon monoxide and biliverdin in the female brain after permanent ischemia.
Tamara Muliaditan et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 24(7), 1617-1628 (2018-01-18)
Purpose: Unprecedented clinical outcomes have been achieved in a variety of cancers by targeting immune checkpoint molecules. This preclinical study investigates heme oxygenase-1 (HO-1), an immunosuppressive enzyme that is expressed in a wide variety of cancers, as a potential immune

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