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SML3111

ETP-47799

≥98% (HPLC)

Synonym(s):

CDK8/19i-47799, CDK8/19i-CNIO-47799, ETP 47799, ETP47799, Lck-IN-1, N-Propyl-3-(4-pyridinyl)imidazo[1,2-b]pyridazin-6-amine

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About This Item

Empirical Formula (Hill Notation):
C14H15N5
CAS Number:
Molecular Weight:
253.30
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

CCCNC1=NN2C(C=C1)=NC=C2C3=CC=NC=C3

InChI key

XTMROGQLIVGYKF-UHFFFAOYSA-N

Biochem/physiol Actions

ETP-47799 is a potent and CDK8-/CDK19-selective cyclin-dependent kinase inhibtor (CDK8/19 IC50 = 2.9/14.1 nM; CDK1/5/9 IC50 = 275/239/124 nM; CDK2/4/6/7 IC50 >1 μM; GSK3β IC50 = 3.14 μM) with additional potency against PDGFRα (IC50 = 3.5 nM). ETP-47799 ( 0.4 μM or 1.1 μM) induces and stabilizes the naive state of murine and human pluripotent stem cells (PSCs) with better efficiency than the commonly used MEK/GSK3 inhibitor cocktail (1μM PD0325901, 1.5μM CHIR 99021).
Potent and CDK8-/CDK19-selective cyclin-dependent kinase inhibtor that induces and stabilizes the naive state of murine and human pluripotent stem cells (PSCs).

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description

≥98% (HPLC)

description

≥98% (HPLC)

description

targeting mouse Cdk8

description

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

-

assay

-

form

powder

form

powder

form

lyophilized powder

form

buffered aqueous glycerol solution

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

-

solubility

-

color

white to beige

color

white to light brown

color

-

color

-


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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