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About This Item
Empirical Formula (Hill Notation):
C14H15N5
CAS Number:
Molecular Weight:
253.30
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Pricing and availability is not currently available.
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
CCCNC1=NN2C(C=C1)=NC=C2C3=CC=NC=C3
InChI key
XTMROGQLIVGYKF-UHFFFAOYSA-N
Biochem/physiol Actions
ETP-47799 is a potent and CDK8-/CDK19-selective cyclin-dependent kinase inhibtor (CDK8/19 IC50 = 2.9/14.1 nM; CDK1/5/9 IC50 = 275/239/124 nM; CDK2/4/6/7 IC50 >1 μM; GSK3β IC50 = 3.14 μM) with additional potency against PDGFRα (IC50 = 3.5 nM). ETP-47799 ( 0.4 μM or 1.1 μM) induces and stabilizes the naive state of murine and human pluripotent stem cells (PSCs) with better efficiency than the commonly used MEK/GSK3 inhibitor cocktail (1μM PD0325901, 1.5μM CHIR 99021).
Potent and CDK8-/CDK19-selective cyclin-dependent kinase inhibtor that induces and stabilizes the naive state of murine and human pluripotent stem cells (PSCs).
1 of 1
This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description ≥98% (HPLC) | description targeting mouse Cdk8 | description Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay - | assay - |
| form powder | form powder | form lyophilized powder | form buffered aqueous glycerol solution |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| solubility DMSO: 2 mg/mL, clear | solubility DMSO: 2 mg/mL, clear (warmed) | solubility - | solubility - |
| color white to beige | color white to light brown | color - | color - |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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