SML2834

SGC-CAMKK2-1

≥98% (HPLC)

• Synonym(s): 2-Cyclopentyl-4-(5-(m-tolyl)furo[2,3-b]pyridin-3-yl)benzoic acid, YL-36
• Empirical Formula (Hill Notation): C₂₆H₂₃NO₃
• CAS Number: 2561494-76-4
• Molecular Weight: 397.47
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: CC1=CC(C2=CN=C(OC=C3C4=CC(C5CCCC5)=C(C(O)=O)C=C4)C3=C2)=CC=C1
• InChI: 1S/C26H23NO3/c1-16-5-4-8-18(11-16)20-13-23-24(15-30-25(23)27-14-20)19-9-10-21(26(28)29)22(12-19)17-6-2-3-7-17/h4-5,8-15,17H,2-3,6-7H2,1H3,(H,28,29)
• InChI key: TXIYVFVMXNFNRX-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Potent and selective CaM kinase kinase (CaMKK) inhibitor with selective affinity toward CAMKK1/2 over other kinases.

SGC-CAMKK2-1 (YL-36) is a potent and selective CaM kinase kinase (CaMKK) inhibitor (CAMKK2 IC₅₀ = 30 nM) that inhibits C4-2 cellular AMPK phosphorylation (IC₅₀ = 1.6 μM) with selective affinity toward CAMKK1/2 over other kinases (404-kinase panel kinome-wide Discoverx screen).

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable