SML2198
sAJM589
≥98% (HPLC)
Synonym(s):
5-Hydroxybenzo[a]phenazine, Benzo[a]phenazin-5-ol
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About This Item
Empirical Formula (Hill Notation):
C16H10N2O
CAS Number:
Molecular Weight:
246.26
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Pricing and availability is not currently available.
assay
≥98% (HPLC)
form
powder
color
yellow to orange
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
−20°C
SMILES string
OC1=C2C(C=CC=C2)=C3C(N=C(C=CC=C4)C4=N3)=C1
InChI key
WZBDRAAGHRCRKM-UHFFFAOYSA-N
Biochem/physiol Actions
Myc inhibitor that disrupts the Myc-Max heterodimer
sAJM589 is a Myc inhibitor that disrupts the Myc-Max heterodimer with an IC50 value of 1.8 μM. sAJM589 was shown to suppress cellular proliferation in a variety of MYC-dependent cancer cell line including strong inhibition of Burkitt lymphoma Raji cell line growth. The mechanism of action of sAJM589 is thought to involve increased ubiquitination of Myc by inhibition of Max binding to Myc, leading to proteasome-mediated degradation.
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This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description clone 9E10, IgG fraction of antiserum, buffered aqueous solution | description clone GT0002, affinity isolated antibody | description affinity isolated antibody |
| form powder | form buffered aqueous solution | form buffered aqueous solution | form buffered aqueous solution |
| assay ≥98% (HPLC) | assay - | assay - | assay - |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| solubility DMSO: 2 mg/mL, clear (warmed) | solubility - | solubility - | solubility - |
| color yellow to orange | color - | color - | color - |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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