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SML2174

Sigma-Aldrich

MS012

≥98% (HPLC)

Synonym(s):

N2-Hexyl-6,7-dimethoxy-N4-(1-methylpiperidin-4-yl)quinazoline-2,4-diamine

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About This Item

Empirical Formula (Hill Notation):
C22H35N5O2
CAS Number:
2089617-83-2
Molecular Weight:
401.55
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

CN(CC1)CCC1NC2=C3C(C=C(OC)C(OC)=C3)=NC(NCCCCCC)=N2

Biochem/physiol Actions

MS012 is a selective G9a-like Protein (GLP) lysine methyl transferase (PKMT) inhibitor with an IC50 value of 7 nM and over 140-fold selectivity for GLP over G9a and other methyl transferases tested.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yan Xiong et al.
Bioorganic & medicinal chemistry, 25(16), 4414-4423 (2017-07-01)
Given the high homology between the protein lysine methyltransferases G9a-like protein (GLP) and G9a, it has been challenging to develop potent and selective inhibitors for either enzyme. Recently, we reported two quinazoline compounds, MS0124 and MS012, as GLP selective inhibitors.
Yan Xiong et al.
Journal of medicinal chemistry, 60(5), 1876-1891 (2017-01-31)
G9a-like protein (GLP) and G9a are highly homologous protein lysine methyltransferases (PKMTs) sharing approximately 80% sequence identity in their catalytic domains. GLP and G9a form a heterodimer complex and catalyze mono- and dimethylation of histone H3 lysine 9 and nonhistone

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