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BIX

Name: BIX
Brand: SIGMA

≥98% (HPLC), molecular chaperone GRP78 inducer, powder

Synonym(s):

2-(3,4-Dihydroxyphenyl)-2-oxoethyl ester thiocyanic acid, BiP protein Inducer X

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About This Item

Empirical Formula (Hill Notation):

C₉H₇NO₃S

CAS Number:

101714-41-4

Molecular Weight:

209.22

UNSPSC Code:

12352200

PubChem Substance ID:

329825455

NACRES:

NA.77

MDL number:

MFCD22415334

Assay:

≥98% (HPLC)

Form:

powder

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Properties

Product Name

BIX, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

OC1=C(O)C=C(C(CSC#N)=O)C=C1

InChI

1S/C9H7NO3S/c10-5-14-4-9(13)6-1-2-7(11)8(12)3-6/h1-3,11-12H,4H2

InChI key

SVFLBLCWKKQKDW-UHFFFAOYSA-N

Description

Application

BIX has been used in cell viability assay.

Biochem/physiol Actions

BIX (BiP protein inducer X) induces the expression of the endoplasmic reticulum chaperone protein GRP78 (glucose regulated protein 78, BiP) leading to an attenuation of the unfolded protein response. BIX protects neuronal cells and retinal cells from ER-stress induced cell death.

BIX is an inducer of molecular chaperone GRP78 (BIP, Glucose regulated protein 78).

Other Notes

air sensitive

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This Item	MABS474	G9043	05989
Sigma-Aldrich SML1073 BIX	Sigma-Aldrich MABS474 Anti-GRP78 Antibody, clone N88	$Anti-GRP78/BiP (ET-21) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich G9043 Anti-GRP78/BiP (ET-21) antibody produced in rabbit	Sigma-Aldrich 05989 Bixin
description ≥98% (HPLC)	description clone N88, from mouse	description IgG fraction of antiserum, buffered aqueous solution	description ≥90.0% (HPLC)
assay ≥98% (HPLC)	assay -	assay -	assay ≥90.0% (HPLC)
form powder	form -	form buffered aqueous solution	form powder
Quality Level 100	Quality Level 100	Quality Level 200	Quality Level 100
storage temp. 2-8°C	storage temp. -	storage temp. −20°C	storage temp. −20°C
solubility DMSO: 20 mg/mL, clear	solubility -	solubility -	solubility -
color white to beige	color -	color -	color -

Pictograms

GHS07

Signal Word

Warning

Storage Class

11 - Combustible Solids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

Hazard Codes

H302,H315,H317,H319

Precautionary Statements

P261 - P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1

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