SML0927
Diapocynin
≥98% (HPLC)
Synonym(s):
1,1′-(6,6′-Dihydroxy-5,5′-dimethoxy[1,1′-biphenyl]-3,3′-diyl)bis-ethanone, 4′,4′′′-Dihydroxy-5′,5′′′-dimethoxy-3′,3′′′-biacetophenone (8CI), Dehydrodiacetovanillone
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About This Item
Empirical Formula (Hill Notation):
C18H18O6
CAS Number:
Molecular Weight:
330.33
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Pricing and availability is not currently available.
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
room temp
Biochem/physiol Actions
Diapocynin, a proposed NADPH oxidase (NOX) inhibitor, is an anti-inflammatory and antioxidant agent.
Diapocynin, a proposed NADPH oxidase (NOX) inhibitor, is an anti-inflammatory and antioxidant agent. Diapocynin attenuates oxidative damage and neuroinflammatory responses in animal model of Parkinson′s disease. Diapocynin reverses deficient motor coordination in LRRK2R1441Gtg mice of PD.
Diapocynin is a covalent dimer of apocynin, and a functional metabolite of the same. It is generated by neutrophil activation via myeloperoxidase-mediated oxidation. Studies show that diapocynin has greater neuroprotection compared to apocynin.
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This Item | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥95% (HPLC) | assay ≥95% (HPLC) | assay - |
| form powder | form powder | form powder | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. room temp | storage temp. −20°C | storage temp. 2-8°C | storage temp. - |
| solubility DMSO: 2 mg/mL, clear (warmed) | solubility DMSO: 20 mg/mL, clear | solubility DMSO: 2 mg/mL, clear | solubility - |
| color white to beige | color light yellow to dark yellow | color white to beige | color - |
signalword
Warning
hcodes
pcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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