SML0632

Fialuridine

≥98% (HPLC), powder, nucleoside analog

• Synonym(s): 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodo-2,4(1H,3H)-Pyrimidinedione, FIAU
• Empirical Formula (Hill Notation): C₉H₁₀FIN₂O₅
• CAS Number: 69123-98-4
• Molecular Weight: 372.09
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825571
• NACRES: NA.77
• MDL number: MFCD00866922
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: Fialuridine, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 5 mg/mL, clear (warmed)
• storage temp.: −20°C
• SMILES string: F[C@H]1[C@H](O)[C@@H](CO)O[C@H]1N2C(NC(C(I)=C2)=O)=O
• InChI: 1S/C9H10FIN2O5/c10-5-6(15)4(2-14)18-8(5)13-1-3(11)7(16)12-9(13)17/h1,4-6,8,14-15H,2H2,(H,12,16,17)/t4-,5+,6-,8-/m1/s1
• InChI key: IPVFGAYTKQKGBM-BYPJNBLXSA-N

Description

General description

Fialuridine (1-(2-deoxy-2-fluoro-β-d-arabinofuranosyl)-5-iodouracil, or FIAU) is an antiviral agent. It is a thymidine-based nucleoside analogue.

Application

Fialuridine has been used in the selection of clones.

Biochem/physiol Actions

Fialuridine is a nucleoside analog antiviral agent.

Fialuridine is a nucleoside analog antiviral agent. The compound displays significant mitochondrial toxicity.

Fialuridine (1-(2-deoxy-2-fluoro-β-d-arabinofuranosyl)-5-iodouracil, or FIAU) and its metabolites blocks DNA polymerase at sites of multiple adjacent analog incorporation, reduces the presence of mtDNA (mitochondrial DNA) and results in mitochondrial structural defects in cultured hepatoblasts. It is considered as an efficient drug against hepatitis B virus (HBV) infection.

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable