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SML0430

PR-619

≥95% (HPLC), deubiquitylating enzymes (DBUs) inhibitor, powder

Synonym(s):

2,6-Diamino-3,5-dithiocyanopyridine, Thiocyanic acid C,C′-(2,6-diamino-3,5-pyridinediyl) ester; 2,6-Diaminopyridine-3,5-bis(thiocyanate)

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Size/SKUAvailabilityPrice
1 mg

Estimated to ship onOctober 21, 2026

€115.00
5 mg

Available to ship TODAYfromSchnelldorf

€332.00

About This Item

Empirical Formula (Hill Notation):
C7H5N5S2
CAS Number:
Molecular Weight:
223.28
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥95% (HPLC)
Form:
powder

€115.00


Estimated to ship onOctober 21, 2026Details


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Product Name

PR-619, ≥95% (HPLC)

Quality Segment

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL (clear solution)

storage temp.

−20°C

SMILES string

Nc1nc(N)c(SC#N)cc1SC#N

InChI

1S/C7H5N5S2/c8-2-13-4-1-5(14-3-9)7(11)12-6(4)10/h1H,(H4,10,11,12)

InChI key

ZXOBLNBVNROVLC-UHFFFAOYSA-N

Application

PR-619 has been used:
  • as a component of lysis buffer and also as a deubiquitinase inhibitor to treat proteins derived from SILAC-labeled Jurkat cells
  • as a pan-deubiquitinase inhibitor to study its effect on adenoassociated virus (AAV) transduction
  • in radioimmunoprecipitation assay buffer (RIPA) buffer used for ubiquitination assays

Biochem/physiol Actions

PR-619 cell permeable, broad spectrum deubiquitylating enzymes (DBUs) inhibitor; general deubiquitylase (DUB) inhibitor.
PR-619 is a cell permeable broad spectrum deubiquitylating enzymes (DBUs) inhibitor. PR-619 induces the accumulation of polyubiquitylated proteins in cells without directly affecting proteasome activity.

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This Item
662141490563486140
description

≥95% (HPLC)

description

The DUB Inhibitor V, PR-619 controls the biological activity of DUB. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

description

99 atom % 13C

description

98 atom % 15N, 99 atom % 13C

assay

≥95% (HPLC)

assay

≥99% (HPLC)

assay

-

assay

-

form

powder

form

solid

form

-

form

-

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

200

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

-

storage temp.

-

solubility

DMSO: 5 mg/mL (clear solution)

solubility

DMSO: 50 mg/mL

solubility

-

solubility

-

color

white to beige

color

light beige to yellow

color

-

color

-


Storage Class

11 - Combustible Solids

WGK

WGK 3



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