Key Documents

View All Documentation

RAD51 Inhibitor B02

Name: RAD51 Inhibitor B02
Brand: SIGMA

≥98% (HPLC), RAD51 recombinase inhibitor, powder

Synonym(s):

3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone

Select a Size

Change View

Size/SKU	Availability	Price

About This Item

Empirical Formula (Hill Notation):

C₂₂H₁₇N₃O

CAS Number:

1290541-46-6

Molecular Weight:

339.39

UNSPSC Code:

12352200

PubChem Substance ID:

329825366

NACRES:

NA.77

MDL number:

MFCD03294274

Assay:

≥98% (HPLC)

Form:

powder

Pricing and availability is not currently available.

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Product Name

RAD51 Inhibitor B02, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to dark brown

solubility

DMSO: ≥5 mg/mL

storage temp.

2-8°C

SMILES string

O=C1N(CC2=CC=CC=C2)C(/C=C/C3=CN=CC=C3)=NC4=C1C=CC=C4

InChI

1S/C22H17N3O/c26-22-19-10-4-5-11-20(19)24-21(13-12-17-9-6-14-23-15-17)25(22)16-18-7-2-1-3-8-18/h1-15H,16H2/b13-12+

InChI key

GEKDQXSPTHHANP-OUKQBFOZSA-N

Description

Application

RAD51 Inhibitor B02 has been used:

to test its effect on the polar body extrusion (PBE) rate in porcine oocytes
for RAD51 inhibition in porcine embryos
as RAD51 inhibitor and to test its effect on targeted nucleotide substitution (TNS) in induced pluripotent stem cells (iPSCs)

Biochem/physiol Actions

B02 (3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone), a pyridinylvinyl-quinazolinone compound is cell-permeable. B02 inhibits human RAD51 recombinase and subsequent nucleofilaments formation. It halts homologous recombination (HR) repair events in cancer cells. B02 favors apoptosis in multiple myeloma and is crucial for sensitizing them to doxorubicin.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item	ABE257	SAB2101936	SAB1406364
Sigma-Aldrich SML0364 RAD51 Inhibitor B02	Sigma-Aldrich ABE257 Anti-RAD51 Antibody	Sigma-Aldrich SAB2101936 Anti-RAD51 antibody produced in rabbit	Sigma-Aldrich SAB1406364 Anti-RAD51 antibody produced in mouse
description ≥98% (HPLC)	description from rabbit, purified by affinity chromatography	description affinity isolated antibody	description purified immunoglobulin, buffered aqueous solution
assay ≥98% (HPLC)	assay -	assay -	assay -
form powder	form -	form buffered aqueous solution	form buffered aqueous solution
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. -	storage temp. −20°C	storage temp. −20°C
solubility DMSO: ≥5 mg/mL	solubility -	solubility -	solubility -
color white to dark brown	color -	color -	color -

Still not finding the right product?

Explore all of our products under RAD51 Inhibitor B02

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.