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About This Item
Empirical Formula (Hill Notation):
C10H8N4O2S2
CAS Number:
Molecular Weight:
280.33
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Pricing and availability is not currently available.
Quality Segment
assay
≥98% (HPLC)
form
powder
color
faintly yellow to dark yellow
solubility
DMSO: ≥15 mg/mL
storage temp.
2-8°C
SMILES string
NS(=O)(=O)c1nn2cc(nc2s1)-c3ccccc3
InChI
1S/C10H8N4O2S2/c11-18(15,16)10-13-14-6-8(12-9(14)17-10)7-4-2-1-3-5-7/h1-6H,(H2,11,15,16)
InChI key
MQUYTXDAVCOCMX-UHFFFAOYSA-N
Biochem/physiol Actions
AEG3284 is a compound that binds to heat shock protein 90 (HSP90), leading to heat shock factor 1 (HSF1) dependent expression of HSP70, an endogenous inhibitor of c-Jun N-terminal kinase (JNK) activity. Treatment of PC12 cells with AEF3284 blocks JNK dependent apoptosis.
AEG3284 is an indirect inhibitor of JNK activity; HSP90 binder.
Features and Benefits
This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description ≥98% (HPLC) | description ≥98% (HPLC) | description ≥95% (HPLC), film |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥95% (HPLC) |
| form powder | form powder | form powder | form film |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 200 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C |
| solubility DMSO: ≥15 mg/mL | solubility DMSO: 10 mg/mL, clear | solubility DMSO: >10 mg/mL | solubility H2O: 0.5 mg/mL, clear |
| color faintly yellow to dark yellow | color faintly yellow, to beige | color white to off-white | color colorless to white |
Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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