Key Documents

Tubastatin A hydrochloride

Name: Tubastatin A hydrochloride
Brand: SIGMA

≥98% (HPLC), Selective HDAC6 inhibitor, powder

Synonym(s):

N-Hydroxy-4-(2-methyl-1,2,3,4-tetrahydro-pyrido[4,3-b]indol-5-ylmethyl)benzamide hydrochloried; N-Hydroxy-4-((2-methyl-3,4-dihydro-1H-pyrido[4,3-b]-indol-5(2H)-yl)methyl)benzamide hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₂₁N₃O₂·HCl

CAS Number:

1310693-92-5

Molecular Weight:

371.86

UNSPSC Code:

12352200

PubChem Substance ID:

329825114

NACRES:

NA.77

MDL number:

MFCD20488052

Assay:

≥98% (HPLC)

Form:

powder

Storage condition:

desiccated

Pricing and availability is not currently available.

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Properties

Product Name

Tubastatin A hydrochloride, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to tan

solubility

DMSO: ≥10 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

O=C(NO)C1=CC=C(CN2C3=C(C=CC=C3)C4=C2CCN(C)C4)C=C1.Cl

InChI

1S/C20H21N3O2.ClH/c1-22-11-10-19-17(13-22)16-4-2-3-5-18(16)23(19)12-14-6-8-15(9-7-14)20(24)21-25;/h2-9,25H,10-13H2,1H3,(H,21,24);1H

InChI key

LJTSJTWIMOGKRJ-UHFFFAOYSA-N

Description

Application

Tubastatin A hydrochloride may be used in HDAC6-mediated cell signaling studies.

Biochem/physiol Actions

Tubastatin A Hydrochloride is a very selective HDAC6 inhibitor.

Tubastatin A is a very selective HDAC6 inhibitor with an IC50 of 4 nM and 100 to over 1000-fold selectivity for HDAC6 over other HDAC classes.

Tubastatin A increases the total numbers of mitochondria and restores the number of moving mitochondria in DRG neurons. It reverses the axonal loss in peripheral neurons in mouse model of Charcot-Marie-Tooth disease. Tubastatin A inhibits the deacetylation of α-tubulin in murine myoblasts.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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Show Differences

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This Item	M7316	SRP3003	A4941
Sigma-Aldrich SML0044 Tubastatin A hydrochloride	Sigma-Aldrich M7316 Monoamine Oxidase A human	Sigma-Aldrich SRP3003 Activin A human	Sigma-Aldrich A4941 Activin A human
description ≥98% (HPLC)	description recombinant, expressed in baculovirus infected BTI insect cells	description recombinant, expressed in E. coli, ≥97% (SDS-PAGE), ≥97% (HPLC), suitable for cell culture	description ≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, lyophilized powder, suitable for cell culture
assay ≥98% (HPLC)	assay -	assay ≥97% (HPLC), ≥97% (SDS-PAGE)	assay ≥95% (SDS-PAGE)
form powder	form liquid	form lyophilized	form lyophilized powder
Quality Level 100	Quality Level 100	Quality Level -	Quality Level 200
storage temp. −20°C	storage temp. −70°C	storage temp. −20°C	storage temp. −20°C
storage condition desiccated	storage condition -	storage condition -	storage condition -
solubility DMSO: ≥10 mg/mL	solubility -	solubility -	solubility -

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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