Anti-THRB Antibody detects endogenous levels of total THRB protein.
Thyroid hormone receptor β; (THRβ) is encoded by the gene mapped to human chromosome 3p. THRβ exist in two isoforms, THRβ1 widely expressed in brain, liver and kidney and THRβ2 expressed specifically in hypothalamus and pituitary. The encoded protein contains a C- terminal ligand-binding and dimerization domain, a DNA-binding domain and a transactivation domain.
Immunogen
The antiserum was produced against synthesized peptide derived from human THRB.
Immunogen Range: 391-440
Biochem/physiol Actions
Thyroid hormone receptor β (THRβ) mediates the biological functions of thyroid hormones (TH). THRβ is down-regulated in several human malignancies including papillary thyroid carcinomas (PTCs). Loss of heterozygosity in THRβ and its proximal microsatellite markers might play a crucial role in tumorigenesis and development in invasive breast cancer. Deletion of the gene coding for THRβ leads to generalized thyroid hormone resistance (GTHR). THRβ plays a vital role in the regulation of specific mRNA and miRNA in T3-induced cardiac hypertrophy and alteration of heart functions in mice.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
American journal of cancer research, 14(4), 1501-1522 (2024-05-10)
Considering the limited research and the prevailing evidence of STAT4's tumor-suppressing role in breast carcinoma (BC) or in breast radiotherapy (RT) sensitivity requires more in-depth exploration. Our study delves into how STAT4, a transcription factor, affects BC cell resistance to
Reduced expression of THR? in papillary thyroid carcinomas: relationship with BRAF mutation, aggressiveness and miR expression.
Rosignolo F
Journal of Endocrinological Investigation, 38, 1283-1289 (2015)
Thyroid hormone receptor beta is essential for development of auditory function.
Nature Genetics, 13, 354-357 (1996)
Loss of heterozygosity in thyroid hormone receptor beta in invasive breast cancer.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
