This product is not a sterile preparation. If the intended use, such as in cell culture, requires a sterile environment, then the stock solution would require filter sterilization. Typically, this is achieved by filtration through a 0.22 um membrane. Alternatively, product S9133 is a γ-irradiated, sterile powder. When reconstituted aseptically using sterile water, this product may be added directly to culture medium.
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https://www.sigmaaldrich.com/product/sigma/s9133
S5261
Sodium selenite
BioReagent, suitable for cell culture, ≥98%
Synonym(s):
Selenious acid, Sodium salt
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About This Item
Linear Formula:
Na2SeO3
CAS Number:
Molecular Weight:
172.94
EC Number:
MDL number:
UNSPSC Code:
12352205
PubChem Substance ID:
NACRES:
NA.75
Pricing and availability is not currently available.
Recommended Products
biological source
synthetic (inorganic)
Quality Level
product line
BioReagent
Assay
≥98%
form
powder
technique(s)
cell culture | mammalian: suitable
mp
>350 °C (lit.)
solubility
water: 50 mg/mL, clear to very slightly hazy, colorless
SMILES string
[Na+].[Na+].[O-][Se]([O-])=O
InChI
1S/2Na.H2O3Se/c;;1-4(2)3/h;;(H2,1,2,3)/q2*+1;/p-2
InChI key
BVTBRVFYZUCAKH-UHFFFAOYSA-L
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Application
Sodium selenite is commonly used as a source of selenium in biological research, where selenium is an essential trace element that is normally provided by serum. Selenium is present in selenoproteins such as glutathione peroxidase and thioredoxin reductase, which contain the selenium analog of cysteine, selenocysteine. In particular, glutathione peroxidase has a role in detoxification in vivo as a scavenger of peroxides. Sodium selenite has been utilized in studies of cell proliferation and cancer research. It has been used to alter gene expression in HepG2 cells as analyzed by cDNA microarrays. Sodium selenite can inhibit zinc finger protein/DNA interactions. Sodium selenite has been shown to alter mitochondrial membrane potentials and thus potentially contribute to apoptosis.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1
Supplementary Hazards
Storage Class Code
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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need filtration (0.2um) after preparation?
1 answer-
Helpful?
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How long does an aliquot of this product in water remain stable at -20 degrees Celsius?
1 answer-
As mentioned on the Product Datasheet, stock solutions of sodium selenite may be frozen. Working aliquots remain active for 30 days at 2-8 °C. The Datasheet can accessed in the DOCUMENTATION section under 'More Documents'. Please see the link below:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/245/224/s5261pis.pdfHelpful?
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What solvent do I need to use? DMSO OK?
1 answer-
This item is soluble in water at 50mg/mL. The solubility in DMSO as not been tested.
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