p53, also known as transformation related protein 53 (TRP53), is encoded by the gene mapped to human chromosome 17p13.1. p53 is a tumor suppressor gene expressed in a wide variety of tissues. The gene codes for a tetrameric nuclear DNA-binding phosphoprotein.
Immunogen
The epitope recognized by PLA0072 maps to a region between residues 50 and 100 of human tumor protein p53 using the numbering given in SwissProt entry P04637 (GeneID 7157).
Biochem/physiol Actions
Tumor suppressor p53 has an ability to induce cell cycle arrest. It also plays a key role in DNA repair, senescence and apoptosis. It binds to simian vacuolating virus 40 (SV40) T-antigen and human papilloma virus E6 protein. Mutation in the p53 gene is associated with the development of various types of cancers, such as breast, ovarian, bladder, colon and lung cancer.
Physical form
Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% sodium azide
Other Notes
p53 is a tumor suppressor protein that is mutated or inactivated in over 50% of human cancers. Loss of function defects in p53 are the cause of the autosomal dominant familial cancer syndrome, Li-Fraumeni syndrome (LFS) that is characterized by the development of a diverse set of malignancies at very early ages. At the cellular level p53 is involved in the negative regulation of cell the cycle via its transactivational control of genes required for cell cycle progression. Depending on the physiological circumstance, p53 can promote growth arrest or apoptosis.
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Storage Class Code
12 - Non Combustible Liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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