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Polyinosinic acid potassium salt

Name: Polyinosinic acid potassium salt
Brand: SIGMA

Homopolymer

Synonym(s):

Poly(I) potassium salt

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About This Item

CAS Number:

26936-41-4

UNSPSC Code:

41106305

NACRES:

NA.51

MDL number:

MFCD00131982

Assay:

≥98% (TLC)

Biological source:

synthetic (organic)

Form:

lyophilized powder

Solubility:

water: 4.80-5.20 mg/mL, clear to hazy, colorless to faintly yellow

Storage temp.:

−20°C

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Properties

biological source

synthetic (organic)

Quality Segment

200

assay

≥98% (TLC)

form

lyophilized powder

solubility

water: 4.80-5.20 mg/mL, clear to hazy, colorless to faintly yellow

storage temp.

−20°C

Description

Application

Polyinosinic acid (Poly(I)) is a homopolymer of inosine that may be used with polycytidylic acid (poly(C)) to form the double-stranded homopolymer (Poly(I) • Poly(C)). TLR3 recognizes double-stranded RNA and is a major effector of the immune response against viral pathogens. (Poly(I) • Poly(C)) is a used as a model RNA to study cell signaling at the level of TLR3. Poly(IC) is a TRIF-dependent toll-like receptor-3 (TLR3) ligand.

Preparation Note

Prepared from IDP using polynucleotide phosphorylase.

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This Item	I3036	P9582	P4404
Sigma-Aldrich P4154 Polyinosinic acid potassium salt	Sigma-Aldrich I3036 Polyinosinic–polycytidylic acid potassium salt	Sigma-Aldrich P9582 Polyinosinic–polycytidylic acid potassium salt	Sigma-Aldrich P4404 Polyguanylic acid potassium salt
description Homopolymer	description γ-irradiated, 10% Poly (I:C) with buffer salts, TLR ligand tested	description 10% Poly (I:C) with buffer salts, TLR ligand tested	description lyophilized powder
biological source synthetic (organic)	biological source -	biological source -	biological source enzyme from (synthesis)
Quality Level 200	Quality Level 200	Quality Level 300	Quality Level 200
form lyophilized powder	form -	form lyophilized powder	form lyophilized powder
assay ≥98% (TLC)	assay (Free nucleotides NMT 1% (TLC))	assay (Free nucleotides NMT 1% (TLC))	assay ≥95% (TLC)
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
solubility water: 4.80-5.20 mg/mL, clear to hazy, colorless to faintly yellow	solubility -	solubility -	solubility water: 19.60-20.40 mg/mL, clear to slightly hazy, colorless to light yellow

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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