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P0314

Sigma-Aldrich

Prostaglandin F methyl ester

~5 mg/mL in methyl acetate, ≥95% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C21H36O5
CAS Number:
Molecular Weight:
368.51
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
Pricing and availability is not currently available.

Assay

≥95% (HPLC)

concentration

~5 mg/mL in methyl acetate

storage temp.

−20°C

SMILES string

CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(=O)OCC

InChI

1S/C22H38O5/c1-3-5-8-11-17(23)14-15-19-18(20(24)16-21(19)25)12-9-6-7-10-13-22(26)27-4-2/h6,9,14-15,17-21,23-25H,3-5,7-8,10-13,16H2,1-2H3/b9-6-,15-14+/t17-,18+,19+,20-,21+/m0/s1

InChI key

KRDFNHLEMLCWKD-GWSKAPOCSA-N

Biochem/physiol Actions

Constricts an isolated human smooth muscle; methyl ester form of prostaglandin F2α which is a luteolytic prostaglandin (induces parturition; pulmonary vasoconstrictor).

Packaging

Packaged under Argon.

Pictograms

FlameExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

Target Organs

Central nervous system

Supplementary Hazards

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

15.0 °F

Flash Point(C)

-9.45 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Mucha et al.
Prostaglandins, leukotrienes, and essential fatty acids, 65(5-6), 271-280 (2002-05-08)
This paper describes a new iodine-125 radioimmunoassay of 9alpha ,11beta-PGF2, and its use for the determination of urinary 9alpha,11beta-prostaglandin F2 after a selective one-step solid-phase extraction. The newly reported immunoassay is based on the use of 125I-tyrosyl methyl ester derivative
L Z Bito
Experimental eye research, 38(2), 181-194 (1984-02-01)
It has recently been shown that prostaglandin (PG)E2 or F2 alpha reduces the intraocular pressure (IOP) of cats and primates when applied topically to the eye in very small doses, and that reduced IOP can be maintained in these species
Y Goh et al.
Japanese journal of ophthalmology, 32(4), 471-480 (1988-01-01)
Studies were carried out of the effects of topically applied prostaglandin (PG) D2 and its metabolites and analogues on the intraocular pressure (IOP) in rabbits, and the results were compared with those of studies using PGE2 and F2 alpha. The
L Z Bito et al.
Experimental eye research, 44(2), 217-226 (1987-02-01)
These experiments were undertaken to determine whether the increased ocular hypotensive potency of topically applied prostaglandin (PG) PGF2 alpha esters, as compared with that of PGF2 alpha free acid, can be accounted for by increased penetration of the eicosanoid moiety
J Rydnert
Acta obstetricia et gynecologica Scandinavica, 65(2), 175-180 (1986-01-01)
The hysterometric technique has been designed to measure the pharmacological effect of active agents upon the human uterine muscle. The physiological background is the fact that smooth muscle contracts under the influence of mechanical stimulation. By applying hysterometry, the effects

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