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4-Methylumbelliferyl β-D-glucopyranoside

Name: 4-Methylumbelliferyl &#946;-<SC>D</SC>-glucopyranoside
Brand: SIGMA

β-glucosidase substrate, fluorogenic, ≥99% (HPLC), powder

Synonym(s):

MUD

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₈O₈

CAS Number:

18997-57-4

Molecular Weight:

338.31

NACRES:

NA.32

PubChem Substance ID:

24896859

UNSPSC Code:

12352204

EC Number:

242-736-7

MDL number:

MFCD00063694

Beilstein/REAXYS Number:

94672

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Properties

Product Name

4-Methylumbelliferyl β-D-glucopyranoside, β-glucosidase substrate

Quality Segment

200

assay

≥99% (HPLC)

form

powder

solubility

DMF: 50 mg/mL, clear, colorless to faintly yellow

fluorescence

λ_ex 316 nm; λ_em 372 nm (pH 9.1), λ_ex 360 nm; λ_em 449 nm (Reaction product)

storage temp.

−20°C

SMILES string

CC1=CC(=O)Oc2cc(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc12

InChI

1S/C16H18O8/c1-7-4-12(18)23-10-5-8(2-3-9(7)10)22-16-15(21)14(20)13(19)11(6-17)24-16/h2-5,11,13-17,19-21H,6H2,1H3/t11-,13-,14+,15-,16-/m1/s1

InChI key

YUDPTGPSBJVHCN-YMILTQATSA-N

Description

Application

4-Methylumbelliferyl β-D-glucopyranoside has been used as substrate:

in glucosylceramidase β enzyme activity assay in lysosome-enriched fractions from primary hippocampal neurons
in β-glucosidase assay during yeast fermentation
to assay glucocerebrosidase 1 (GBA1)-related glucosidase activity in macrophage cell line (RAW)

Biochem/physiol Actions

4-Methylumbelliferyl β-D-glucopyranoside is a synthetic enzymatic substrate for glycosidase. It has been used as substrate for the β- glucosidase from enterococci.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

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This Item	M2405	69602	M6018
Sigma-Aldrich M3633 4-Methylumbelliferyl β-D-glucopyranoside	Sigma-Aldrich M2405 4-Methylumbelliferyl β-D-lactopyranoside	Sigma-Aldrich 69602 4-Methylumbelliferyl-β-D-glucuronide hydrate	Sigma-Aldrich M6018 4-Methylumbelliferyl β-D-cellobioside
description β-glucosidase substrate	description β-galactosidase substrate	description suitable for fluorescence, ≥99.0% (HPLC)	description glucanase substrate
assay ≥99% (HPLC)	assay ≥98.00% (TLC)	assay ≥99.0% (HPLC)	assay ≥98.00% (TLC)
solubility DMF: 50 mg/mL, clear, colorless to faintly yellow	solubility water: 9.80-10.20 mg/mL, clear, colorless to faintly yellow	solubility DMSO: 50 mg/mL, clear, colorless to very faintly yellow	solubility water: 19.60-20.40 mg/mL, clear, colorless to faintly yellow
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level 200
form powder	form powder	form powder or crystals	form powder
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C
fluorescence λ_ex 360 nm; λ_em 449 nm (Reaction product), λ_ex 316 nm; λ_em 372 nm (pH 9.1)	fluorescence λ_ex 365 nm; λ_em 445 nm (after enzymatic degradation)	fluorescence λ_ex 365 nm; λ_em 445 nm in 0.1 M phosphate pH 6.5	fluorescence -

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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