D9305

1-Deoxynojirimycin hydrochloride

• Synonym(s): 1,5-Dideoxy-1,5-imino-D-sorbitol hydrochloride
• Empirical Formula (Hill Notation): C₆H₁₃NO₄ · HCl
• CAS Number: 73285-50-4
• Molecular Weight: 199.63
• UNSPSC Code: 12352201
• NACRES: NA.32
• PubChem Substance ID: 24278397
• MDL number: MFCD00133247
• Beilstein/REAXYS Number: 3563225

Properties

• assay: ≥98% (TLC)
• Quality Segment: 200
• form: powder
• solubility: water: 19.60-20.40 mg/mL, clear, colorless
• antibiotic activity spectrum: viruses
• mode of action: enzyme | inhibits
• storage temp.: 2-8°C
• SMILES string: Cl[H].OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
• InChI: 1S/C6H13NO4.ClH/c8-2-3-5(10)6(11)4(9)1-7-3;/h3-11H,1-2H2;1H/t3-,4+,5-,6-;/m1./s1
• InChI key: ZJIHMALTJRDNQI-VFQQELCFSA-N
• Gene Information: human ... GAA(2548)

Description

General description

Chemical structure: glucosamine

Application

1-Deoxynojirimycin hydrochloride has been used

• to study its effects on the loss-of-function of N-glycosylation pathway on hair cell regeneration
• as an endoplasmic reticulum (ER) α-glucosidase I and II inhibitor to study its effects on TMED3-cystic fibrosis transmembrane conductance regulator (CFTR) interaction
• as an insect trehalase inhibitor in TREH inhibition bioassay

Biochem/physiol Actions

α-Glucosidase inhibitor

1-Deoxynojirimycin (DNJ) is a naturally occurring alkaloid azasugar or iminosugar. It is observed in mulberry leaves, Commelina communis, and bacterial strains including Bacillus and Streptomyces species. DNJ acts as an α-glucosidase inhibitor and exhibits anti-viral anti-diabetic, anti-inflammatory, anti-obesity, and antioxidant properties.

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): Eyeshields, Gloves, type N95 (US)