D4526

Doxepin hydrochloride

≥98% (GC), norepinephrine uptake inhibitor, powder

• Synonym(s): 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepine hydrochloride
• Empirical Formula (Hill Notation): C₁₉H₂₁NO · HCl
• CAS Number: 1229-29-4
• Molecular Weight: 315.84
• NACRES: NA.77
• PubChem Substance ID: 24278093
• UNSPSC Code: 12352200
• EC Number: 214-966-8
• MDL number: MFCD00079135
• Assay: ≥98% (GC)
• Form: powder

Properties

• Product Name: Doxepin hydrochloride, ~85% E-isomer basis, ≥98% (GC), 15% Z-isomer basis, powder
• Quality Segment: 200
• assay: ≥98% (GC)
• form: powder
• composition: Z-isomer, 15% , E-isomer, ~85%
• color: white to off-white
• solubility: 1 M HCl: 50 mg/mL, H₂O: soluble
• originator: Boehringer Ingelheim
• SMILES string: Cl[H].CN(C)CC\C=C1/c2ccccc2COc3ccccc13
• InChI: 1S/C19H21NO.ClH/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19;/h3-6,8-12H,7,13-14H2,1-2H3;1H/b17-11+;
• InChI key: MHNSPTUQQIYJOT-SJDTYFKWSA-N
• Gene Information: human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133), HRH1(3269), HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)

Description

General description

Doxepin is used to treat chronic idiopathic urticaria, chronic pain and anxiety. Doxepin exhibits antiserotonergic properties.

Biochem/physiol Actions

Tricyclic antidepressant that is a more potent inhibitor of norepinephrine uptake than of serotonin uptake; antagonist at H₁ histamine, muscarinic cholinergic, and α-adrenoreceptors.

Features and Benefits

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Other Notes

Mixture of cis- and trans-isomers

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges