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DCB

Name: DCB
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

3,3′-Dichlorobenzaldazine, NSC 67224

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About This Item

Empirical Formula (Hill Notation):

C₁₄H₁₀Cl₂N₂

CAS Number:

6971-97-7

Molecular Weight:

277.15

NACRES:

NA.77

PubChem Substance ID:

24724458

UNSPSC Code:

12352200

MDL number:

MFCD00556081

Assay:

≥98% (HPLC)

Form:

solid

Storage condition:

desiccated, under inert gas

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Properties

Quality Segment

100

assay

≥98% (HPLC)

form

solid

storage condition

desiccated, under inert gas

color

yellow

solubility

DMSO: ~6.8 mg/mL, H₂O: insoluble

storage temp.

2-8°C

SMILES string

Clc1cccc(\C=N\N=C\c2cccc(Cl)c2)c1

InChI

1S/C14H10Cl2N2/c15-13-5-1-3-11(7-13)9-17-18-10-12-4-2-6-14(16)8-12/h1-10H/b17-9+,18-10+

InChI key

XMOVWXSCYLINBJ-BEQMOXJMSA-N

Description

Biochem/physiol Actions

3,3′-dichlorobenzaldazine (DCB) serves as an allosteric ligand with neutral cooperativity. It helps to block the positive allosteric regulation of mGluRs (metabotropic glutamate receptor subtype 5 (mGluR5) with the help of 3,3′-difluorobenzaldazine (DFB) and the negative modulatory effect of 3,3′-dimethoxybenzaldazine (DMeOB).

Neutral allosteric modulator of the metabotropic glutamate receptor mGluR₅.

Features and Benefits

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item	T0202	SML0710	A7980
Sigma-Aldrich D1068 DCB	Sigma-Aldrich T0202 Tocainide hydrochloride	Sigma-Aldrich SML0710 DDRI-18	Sigma-Aldrich A7980 AC-41848 hydrate
description ≥98% (HPLC), solid	description ≥98% (HPLC), solid	description ≥98% (HPLC)	description ≥98% (HPLC), solid
form solid	form solid	form powder	form solid
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
storage condition under inert gas, desiccated	storage condition under inert gas, desiccated	storage condition -	storage condition desiccated, under inert gas
solubility H₂O: insoluble, DMSO: ~6.8 mg/mL	solubility H₂O: ≥5 mg/mL, DMSO: >20 mg/mL	solubility DMSO: 10 mg/mL	solubility DMSO: ~14 mg/mL, H₂O: >5 mg/mL

Pictograms

GHS05,GHS07,GHS09

Signal Word

Danger

Hazard Codes

H302,H315,H317,H318,H335,H410

Precautionary Statements

P261 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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