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Cucurbitacin I hydrate

Name: Cucurbitacin I hydrate
Brand: SIGMA

≥95% (HPLC), solid

Synonym(s):

2,16α,20,25-Tetrahydroxy-9-methyl-19-Nor-9β,10α-lanosta-1,5,23-triene-3,11,22-trione, Elatericin B, JSI-124, NSC 521777

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About This Item

Empirical Formula (Hill Notation):

C₃₀H₄₂O₇ · xH₂O

CAS Number:

2222-07-3

Molecular Weight:

514.65 (anhydrous basis)

MDL number:

MFCD09971044

UNSPSC Code:

12352200

PubChem Substance ID:

329775065

EC Number:

218-736-8

NACRES:

NA.77

Assay:

≥95% (HPLC)

Form:

solid

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Properties

Quality Segment

100

assay

≥95% (HPLC)

form

solid

color

white to off-white

solubility

DMSO: >5 mg/mL

storage temp.

−20°C

SMILES string

O.CC(C)(O)\C=C\C(=O)[C@](C)(O)[C@H]1[C@H](O)C[C@@]2(C)[C@@H]3CC=C4[C@@H](C=C(O)C(=O)C4(C)C)[C@]3(C)C(=O)C[C@]12C

InChI

1S/C30H42O7.H2O/c1-25(2,36)12-11-21(33)30(8,37)23-19(32)14-27(5)20-10-9-16-17(13-18(31)24(35)26(16,3)4)29(20,7)22(34)15-28(23,27)6;/h9,11-13,17,19-20,23,31-32,36-37H,10,14-15H2,1-8H3;1H2/b12-11+;/t17-,19-,20+,23+,27+,28-,29+,30+;/m1./s1

InChI key

ZKDSPEWKSJCXQE-NEBRQAMTSA-N

Description

Biochem/physiol Actions

Cucurbitacin I (JSI-124) is a novel selective inhibitor of the janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway with anti-proliferative and anti-tumor properties.

Cucurbitacin I is a novel selective JAK/STAT3 inhibitor.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the JAKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Show Differences

1 of 1

This Item	C8499	D1756	SML1523
Sigma-Aldrich C4493 Cucurbitacin I hydrate	Sigma-Aldrich C8499 Cucurbitacin B hydrate	Sigma-Aldrich D1756 Dexamethasone	Sigma-Aldrich SML1523 Estetrol
description ≥95% (HPLC), solid	description ≥97% (HPLC)	description ≥98% (HPLC), powder	description ≥98% (HPLC)
assay ≥95% (HPLC)	assay ≥97% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form solid	form powder	form powder	form powder
Quality Level 100	Quality Level 100	Quality Level 200	Quality Level 100
storage temp. −20°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C
solubility DMSO: >5 mg/mL	solubility DMSO: 10 mg/mL, clear	solubility methanol: 25 mg/mL	solubility DMSO: 20 mg/mL, clear
color white to off-white	color white to beige	color off-white	color -

Pictograms

GHS06

Signal Word

Danger

Hazard Codes

H300

Precautionary Statements

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 1 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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