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4-Chloro-DL-phenylalanine methyl ester hydrochloride

Name: 4-Chloro-<SC>DL</SC>-phenylalanine methyl ester hydrochloride
Brand: SIGMA

Tryptophan hydroxylase inhibitor, powder

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About This Item

Linear Formula:

ClC₆H₄CH₂CH(NH₂)CO₂CH₃·HCl

CAS Number:

14173-40-1

Molecular Weight:

250.12

NACRES:

NA.32

PubChem Substance ID:

24278310

UNSPSC Code:

12352209

EC Number:

238-024-0

MDL number:

MFCD00012530

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Properties

Product Name

4-Chloro-DL-phenylalanine methyl ester hydrochloride,

form

powder

Quality Segment

200

mp

186-189 °C (lit.)

storage temp.

−20°C

SMILES string

Cl.COC(=O)C(N)Cc1ccc(Cl)cc1

InChI

1S/C10H12ClNO2.ClH/c1-14-10(13)9(12)6-7-2-4-8(11)5-3-7;/h2-5,9H,6,12H2,1H3;1H

InChI key

GCBCWTWQAFLKJG-UHFFFAOYSA-N

Gene Information

human ... TPH1(7166), TPH2(121278)

Description

General description

4-Chloro-DL-phenylalanine methyl ester hydrochloride stimulates glucose intolerance in pregnant mice. Studies have shown that 4-Chloro-DL-phenylalanine methyl ester hydrochloride is associated with cognitive defects in rodents.

Application

4-Chloro-DL-phenylalanine methyl ester hydrochloride has been used to induce 5-hydroxytryptamine (5-HT) depletion in rats.

Biochem/physiol Actions

Tryptophan hydroxylase inhibitor.

Tryptophan hydroxylase inhibitor. Crosses blood brain barrier better than p−chlorophenylalanine.

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This Item	C6506	851299	862126
Sigma-Aldrich C3635 4-Chloro-DL-phenylalanine methyl ester hydrochloride	Sigma-Aldrich C6506 4-Chloro-DL-phenylalanine	Sigma-Aldrich 851299 4-Nitro-DL-phenylalanine	Sigma-Aldrich 862126 3,4-Dehydro-DL-proline
description -	description -	description 98%	description 98%
Quality Level 200	Quality Level 100	Quality Level 200	Quality Level 100
form powder	form solid	form powder	form crystals
Gene Information human ... TPH1(7166), TPH2(121278)	Gene Information human ... TPH1(7166), TPH2(121278)	Gene Information -	Gene Information -
storage temp. −20°C	storage temp. room temp	storage temp. -	storage temp. -
mp 186-189 °C (lit.)	mp >240 °C (dec.) (lit.)	mp 236-237 °C (dec.) (lit.)	mp 245 °C (dec.) (lit.)

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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