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C2020
α-Cyano-4-hydroxycinnamic acid
≥98% (TLC), powder, monocarboxylic acid transport inhibitor
Synonym(s):
α-CCA, α-CHCA, α-Cyano, 4-HCCA, ACCA
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About This Item
Linear Formula:
HOC6H4CH=C(CN)CO2H
CAS Number:
Molecular Weight:
189.17
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352106
EC Number:
248-879-1
MDL number:
Beilstein/REAXYS Number:
3271427
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Product Name
α-Cyano-4-hydroxycinnamic acid, ≥98% (TLC), powder
Quality Level
assay
≥98% (TLC)
form
powder
color
yellow
mp
245-250 °C (lit.)
solubility
H2O: slightly soluble, methanol: water: soluble, polar organic solvents: soluble
storage temp.
2-8°C
SMILES string
OC(=O)\C(=C\c1ccc(O)cc1)C#N
InChI
1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)/b8-5+
InChI key
AFVLVVWMAFSXCK-VMPITWQZSA-N
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Related Categories
1 of 4
This Item | |||
|---|---|---|---|
| form powder | form powder | form powder | form solid |
| assay ≥98% (TLC) | assay - | assay 97% | assay - |
| Quality Level 300 | Quality Level 500 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. room temp | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility H2O: slightly soluble, polar organic solvents: soluble, methanol: water: soluble | solubility - | solubility methanol: soluble 50 mg/mL, clear to slightly hazy, light yellow to yellow | solubility methanol: 10 mg/mL, clear |
| color yellow | color - | color - | color - |
Application
α-Cyano-4-hydroxycinnamic acid has been used to block monocarboxylate transporters.
α-Cyano-4-hydroxycinnamic acid is a useful hydrophobic matrix solution for matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. Antibiotics, peptide nucleic acids (a new class of DNA mimics), and proteins with masses as high as 66,000 Da have been successfully analyzed by using this as a matrix solution.
signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1B
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Adaptive cellular mechanisms in response to Glutamine-starvation
Eliasen MM, et al.
Frontiers in Bioscience, 11, 3199-3211 (2006)
U Schneider et al.
Neuroscience, 53(4), 1153-1162 (1993-04-01)
Exposure of nervous tissue to hypoxia results in interstitial acidification. There is evidence for concomitant decrease in extracellular pH to the increase in tissue lactate. In the present study, we used double-barrelled pH-sensitive microelectrodes to investigate the link between lactate
Elizabeth Csaszar et al.
Biotechnology and bioengineering, 103(2), 402-412 (2009-03-07)
An automated delivery system for cell culture applications would permit studying more complex culture strategies and simplify measures taken to expose cells to unstable molecules. We are interested in understanding how intracellular TAT-HOXB4 protein concentration affects hematopoietic stem cell (HSC)
C Emmons
The American journal of physiology, 276(4 Pt 2), F635-F643 (1999-04-13)
To functionally characterize transport properties of the apical anion exchanger of rabbit beta-intercalated cells, the mean change in anion exchange activity, dpHi/dt (where pHi is intracellular pH), was measured in response to lumen Cl- replacement with gluconate in perfused cortical
R J Williams et al.
Neuroscience, 74(2), 461-468 (1996-09-01)
Glucose deprivation potentiates the glutamate receptor-evoked release of arachidonic acid from cultured mouse striatal neurons. In this study we investigated whether this potentiation would be modified by the end-products of glycolysis. These enhanced responses were completely reversed by the addition
Related Content
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C2020-10G | 04061833475003 |
| C2020-25G | 04061833475010 |
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What can be used for solublization of α-Cyano-4-hydroxycinnamic acid?
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α-Cyano-4-hydroxycinnamic acid (α-CCA, α-CHCA, α-Cyano, 4-HCCA, ACCA) is soluble in methanol (up to 50 mg/ml). It is also soluble at 10 mg/ml using 50% acetonitrile in 0.05% TFA for MALDI-MS. The acetonitrile concentration can be adjusted for individual preferences.For biological applications, it has been solubilized at 100 mM in DMSO or 50 mM in ethanol.
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