Key Documents

S-(−)-Carbidopa

Name: S-(−)-Carbidopa
Brand: SIGMA

≥98% (TLC), powder

Synonym(s):

(S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropanoic acid, S-(−)-α-Hydrazino-3,4-dihydroxy-2-methylbenzenepropanoic acid

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₄N₂O₄

CAS Number:

28860-95-9

Molecular Weight:

226.23

NACRES:

NA.77

PubChem Substance ID:

24892402

UNSPSC Code:

12352202

EC Number:

249-271-9

MDL number:

MFCD00069231

Assay:

≥98% (TLC)

Form:

powder

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Properties

Quality Segment

200

assay

≥98% (TLC)

form

powder

solubility

methanol and 1 drop HCl: 4.90-5.10 mg/mL, clear, colorless to faintly yellow

storage temp.

−20°C

SMILES string

CC(Cc1ccc(O)c(O)c1)(NN)C(O)=O

InChI

1S/C10H14N2O4/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6/h2-4,12-14H,5,11H2,1H3,(H,15,16)/t10-/m0/s1

InChI key

TZFNLOMSOLWIDK-JTQLQIEISA-N

Gene Information

human ... DDC(1644)

Description

General description

Carbidopa is used for treating restless legs (RL) syndrome and periodic leg movements in sleep (PLMS). Carbidopa along with levodopa is used to treat Parkinson′s disease.

Biochem/physiol Actions

Peripheral inhibitor of L-aromatic amino acid decarboxylase.

Peripheral inhibitor of L-aromatic amino acid decarboxylase. When co-administered with L-DOPA, it prevents extra-CNS conversion to dopamine, thereby increasing CNS concentrations of effective compounds. Selectively cytotoxic to human pulmonary carcinoid and small cell lung carcinoma cells by increasing H₂O₂ in these cell lines, which are sensitive to reactive oxygen species.

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This Item	C0460000	E101
Sigma-Aldrich C1335 S-(−)-Carbidopa	C0460000 Carbidopa	Sigma-Aldrich E101 S-(−)-Eticlopride hydrochloride
description ≥98% (TLC), powder	description European Pharmacopoeia (EP) Reference Standard	description ≥98% (HPLC), powder
assay ≥98% (TLC)	assay -	assay ≥98% (HPLC)
form powder	form -	form powder
Quality Level 200	Quality Level -	Quality Level 100
storage temp. −20°C	storage temp. -	storage temp. -
solubility methanol and 1 drop HCl: 4.90-5.10 mg/mL, clear, colorless to faintly yellow	solubility -	solubility 0.1 M HCl: soluble 7 mg/mL, H₂O: soluble >10 mg/mL, ethanol: soluble 2.6 mg/mL
Gene Information human ... DDC(1644)	Gene Information human ... DDC(1644)	Gene Information human ... DRD2(1813)

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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