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C124

β-CFT naphthalenedisulfonate monohydrate

solid

Synonym(s):

(−)-2-β-Carbomethoxy-3-β-(4-fluorophenyl)tropane 1,5-naphthalenedisulfonate monohydrate, WIN 35,428 naphthalenedisulfonate monohydrate

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About This Item

Empirical Formula (Hill Notation):
C16H20FNO2 · C10H8O6S2 · H2O
CAS Number:
77210-32-3
Molecular Weight:
583.65
NACRES:
NA.77
PubChem Substance ID:
24892389
UNSPSC Code:
12352200
MDL number:
MFCD11044874
Form:
solid
Quality level:
100
Pricing and availability is not currently available.
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form

solid

Quality Level

100

optical activity

[α]25/D −62.5°, c = 1.0 in H2O(lit.)

drug control

USDEA Schedule II

color

white

solubility

H2O: soluble

storage temp.

2-8°C

SMILES string

O.OS(=O)(=O)c1cccc2c(cccc12)S(O)(=O)=O.COC(=O)[C@@H]3C4CCC(C[C@@H]3c5ccc(F)cc5)N4C

InChI

1S/C16H20FNO2.C10H8O6S2.H2O/c1-18-12-7-8-14(18)15(16(19)20-2)13(9-12)10-3-5-11(17)6-4-10;11-17(12,13)9-5-1-3-7-8(9)4-2-6-10(7)18(14,15)16;/h3-6,12-15H,7-9H2,1-2H3;1-6H,(H,11,12,13)(H,14,15,16);1H2/t12-,13+,14+,15-;;/m0../s1

InChI key

XSJPWVYASBDEJI-YEVYTSHMSA-N

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This Item
SML2008A155239785
β-CFT naphthalenedisulfonate monohydrate solid

Sigma-Aldrich

C124

β-CFT naphthalenedisulfonate monohydrate

Tiotropium bromide monohydrate ≥98% (HPLC)

Sigma-Aldrich

SML2008

Tiotropium bromide monohydrate

trans-(±)-ACPD monohydrate solid, ≥97% (NMR)

Sigma-Aldrich

A155

trans-(±)-ACPD monohydrate

Cyclophosphamide Monohydrate A widely used anti-neoplastic agent that also displays immunosuppressant properties.

Sigma-Aldrich

239785

Cyclophosphamide Monohydrate

form

solid

form

powder

form

solid

form

solid

drug control

USDEA Schedule II

drug control

-

drug control

-

drug control

-

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

solubility

H2O: soluble

solubility

H2O: 2 mg/mL, clear

solubility

H2O: 1 mg/mL

solubility

water: 30 mg/mL

color

white

color

white to beige

color

white

color

white

Biochem/physiol Actions

Cocaine analog that inhibits the dopamine, norepinephrine, and serotonin transporters with Kis of 26.1 nM, 31.9 nM, and 127 nM, respectively. [11C]-β-CFT and [18F]-β-CFT are ligands for PET imaging of the dopamine transporter in vivo.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Repr. 2 - Skin Sens. 1

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
125K46033
125K46032
125K46031
125K4603
085K4626

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M Haaparanta et al.
Synapse (New York, N.Y.), 23(4), 321-327 (1996-08-01)
We describe the 18F-radiolabelling synthesis (18F; T(1/2) = 109.8 min) of 2-beta-carbomethoxy-3 beta-(4-fluorophenyl)tropane (also known as CFT or WIN 35,428) and the biodistribution of this compound in rats. 18F-labelled CFT has high chemical and radiochemical purity and relatively high specific
Tingting Huang et al.
Clinical nuclear medicine, 37(8), 743-747 (2012-07-13)
Fully automated synthesis of 11C-labeled 2β-carbomethoxy-3β-(4-fluorophenyl)tropane (11C CFT) as a dopamine transporter positron emission tomography (PET) tracer is performed with Sep-Pak purification, which cannot separate 11C CFT from nor-β-CFT and will result in the residual precursor nor-β-CFT in the final
Yan-Fen Zhang et al.
Nuclear medicine and biology, 38(8), 1205-1212 (2011-07-12)
Alterations of dopamine in striatal presynaptic terminals play an important role in the hypoxic-ischemic (HI) brain injury. Quantification of DAT levels in the presynaptic site using (11)C-N-2-carbomethoxy-3-(4-fluorophenyl)-tropane ((11)C-CFT) with positron emission tomography (PET) was applied in studies for Parkinson's disease.
Imaging striatal dopaminergic function in phospholipase A2 group VI-related parkinsonism.
Pankaj Agarwal et al.
Movement disorders : official journal of the Movement Disorder Society, 27(13), 1698-1699 (2012-11-30)
Y Ouchi et al.
Annals of neurology, 45(5), 601-610 (1999-05-13)
We investigated changes in the kinetics in the binding of the dopamine transporter probe 2-beta-carbomethoxy-3beta-(4-[11C]fluorophenyl)tropane (beta-CFT) in living brain by compartmental analysis, using positron emission tomography in unmedicated patients with Parkinson's disease (PD) (Hoehn and Yahr stages I-II). With dynamic
View All Related Papers

Global Trade Item Number

SKUGTIN
C124-5MG04061832089560

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