B3501

Betaine hydrochloride

synthetic (organic), ≥99%, osmoprotectant, powder or crystals

• Synonym(s): (Carboxymethyl)trimethylammonium hydrochloride
• Linear Formula: (CH₃)₃N⁺CH₂COOH · Cl^-
• CAS Number: 590-46-5
• Molecular Weight: 153.61
• NACRES: NA.77
• PubChem Substance ID: 24278266
• UNSPSC Code: 12352202
• EC Number: 209-683-1
• MDL number: MFCD00011903
• Beilstein/REAXYS Number: 3916181

Properties

• Product Name: Betaine hydrochloride, ≥99%
• biological source: synthetic (organic)
• Quality Segment: 100
• assay: ≥99%
• form: powder or crystals
• mp: 241-242 °C (lit.)
• solubility: water: 50 mg/mL, clear, colorless
• storage temp.: room temp
• SMILES string: [Cl-].C[N+](C)(C)CC(O)=O
• InChI: 1S/C5H11NO2.ClH/c1-6(2,3)4-5(7)8;/h4H2,1-3H3;1H
• InChI key: HOPSCVCBEOCPJZ-UHFFFAOYSA-N
• Gene Information: human ... BHMT(635), BHMT2(23743)

Description

General description

Betaine (trimethyl glycine) is an osmoprotectant, which is highly effective than proline. It is formed in from choline. Betaine is usually present in grains, spinach, beets, broccoli, shellfish and marine algae.

Application

Betaine hydrochloride has been used as a component of fixative in HEPES or cacodylate buffer to improve preservation of the ultrastructural morphology of human spermatozoa.

Biochem/physiol Actions

Betaine hydrochloride can decrease hepatotoxicity, that is stimulated by ethanol.

End-product of oxidative metabolism of choline, betaine is a general methyl donor, in particular in a minor pathway of methionine biosynthesis. It is used to treat homocystinuria, which is a defect in the major pathway of methionine biosynthesis.

Safety Information

• pictograms: GHS05
• signalword: Danger
• hcodes: H318
• pcodes: P280 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1
• Storage Class: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves