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Angiotensin Converting Enzyme from porcine kidney

Name: Angiotensin Converting Enzyme from porcine kidney
Brand: SIGMA

lyophilized powder, ≥10 units/mg protein (Bradford)

Synonym(s):

ACE, Peptidyl-dipeptidase A

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About This Item

CAS Number:

9015-82-1

UNSPSC Code:

12352200

NACRES:

NA.32

EC Number:

3.4.15.1 (BRENDA, IUBMB)

MDL number:

MFCD00130325

eCl@ss:

42010109

Specific activity:

≥10 units/mg protein (Bradford)

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Properties

form

lyophilized powder

Quality Segment

200

specific activity

≥10 units/mg protein (Bradford)

UniProt accession no.

A0A480IQM9

shipped in

dry ice

storage temp.

−20°C

Gene Information

pig ... ACE(613133)

Description

General description

Angiotensin converting enzyme (ACE) is encoded by the gene, mRNA-decapping enzyme subunit 1 (DCP1). It is a zinc metalloprotease, which belongs to the M2 family.

ACE is a monomer with molecular weight of ~170 kDa
pH range for activity: 7-8.5
Temperature optimum: 37 °C
Zinc is required for activity
Inhibitors: captopril, enalaprilat, lisinopril etc. (1-10 μM)

Application

Angiotensin converting enzyme from porcine kidney has been used in in vitro angiotensin-converting enzyme (ACE) inhibition assay.

Biochem/physiol Actions

Angiotensin converting enzyme (ACE) catalyzes the conversion of angiotensin I to angiotensin II, which regulates the fluid-electrolyte balance and systemic blood pressure. ACE inhibits the vasodilator, bradykinin. ACE inhibitors are used to treat high blood pressure.

Removes C-terminal dipeptides from susceptible substrates, e.g., angiotensin I and bradykinin.

Physical form

Lyophilized powder containing Tris buffer salts.

Other Notes

One unit will produce 1.0 ·μmole of hippuric acid from Hippuryl-His-Leu per min in 50 mM HEPES and 300 mM NaCl at pH 8.3 at 37 °C.

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This Item	SAE0075	P6675	L5006
Sigma-Aldrich A2580 Angiotensin Converting Enzyme from porcine kidney	Sigma-Aldrich SAE0075 Angiotensin Converting Enzyme, ACE, human	Sigma-Aldrich P6675 Prolidase from porcine kidney	Sigma-Aldrich L5006 Leucine Aminopeptidase, microsomal from porcine kidney
description lyophilized powder, ≥10 units/mg protein (Bradford)	description recombinant, ≥10 U/mg, expressed in HEK 293 cells	description lyophilized powder, ≥100 units/mg protein	description Type IV-S, ammonium sulfate suspension, 10-40 units/mg protein (Bradford)
specific activity ≥10 units/mg protein (Bradford)	specific activity ≥10 U/mg	specific activity ≥100 units/mg protein	specific activity 10-40 units/mg protein (Bradford)
Gene Information pig ... ACE(613133)	Gene Information -	Gene Information -	Gene Information -
form lyophilized powder	form lyophilized powder	form lyophilized powder	form ammonium sulfate suspension
shipped in dry ice	shipped in dry ice	shipped in -	shipped in -
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C
UniProt accession no. A0A480IQM9	UniProt accession no. P12821	UniProt accession no. -	UniProt accession no. -