Key Documents

View All Documentation

Cotrimoxazole

Name: Cotrimoxazole
Brand: SIGMA

Ready Made Solution, 100 mg/mL in DMSO

Synonym(s):

Trimethoprim-Sulfamethoxazole, TMP-SMX

Select a Size

Change View

Size/SKU	Availability	Price

About This Item

Empirical Formula (Hill Notation):

C₁₄H₁₈N₄O₃· 5 C₁₀H₁₁N₃O₃S

CAS Number:

8064-90-2

Molecular Weight:

1556.71

MDL number:

MFCD00242808

UNSPSC Code:

51102829

NACRES:

NA.85

Pricing and availability is not currently available.

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Quality Segment

200

form

liquid, ready-to-use solution

concentration

100 mg/mL in DMSO

color

colorless to faint yellow

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, fungi, parasites

mode of action

DNA synthesis | interferes

shipped in

dry ice

storage temp.

−20°C

SMILES string

[S](=O)(=O)(Nc4n[o]c(c4)C)c3ccc(cc3)N.Nc1nc(c(cn1)Cc2cc(c(c(c2)OC)OC)OC)N

InChI

1S/C14H18N4O3.C10H11N3O3S/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2-6H,11H2,1H3,(H,12,13)

InChI key

WZRJTRPJURQBRM-UHFFFAOYSA-N

Description

Application

Cotrimoxazole has been used as an antimicrobial agent.

Biochem/physiol Actions

Cotrimoxazole, a combination of trimethoprim and sulfamethoxazole, interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to dihydrofolate reductase (DHFR) which inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF), resulting in an antimicrobial effect. Sulfamethoxazole interferes with the synthesis of nucleic acids in sensitive microorganisms by blocking the conversion of p-aminobenzoic acid to the coenzyme dihydrofolic acid. The net effect of these actions is to inhibit thymidine synthesis which prevents bacterial DNA synthesis.

Packaging

1ml

Preparation Note

prepared using a 1:5 mixture of trimethoprim:sulfamethoxazole

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item	SML3191	SBR00024	33746
Sigma-Aldrich A2487 Cotrimoxazole	Sigma-Aldrich SML3191 Cotrimoxazole	Sigma-Aldrich SBR00024 Trimethoprim	Supelco 33746 Moxidectin
description Ready Made Solution, 100 mg/mL in DMSO	description ≥98% (HPLC)	description Ready Made Solution, 25 mg/mL in DMSO	description VETRANAL^®, analytical standard
antibiotic activity spectrum Gram-positive bacteria, fungi, parasites, Gram-negative bacteria	antibiotic activity spectrum -	antibiotic activity spectrum Gram-positive bacteria, mycobacteria, Gram-negative bacteria	antibiotic activity spectrum -
Quality Level 200	Quality Level 100	Quality Level -	Quality Level 100
form ready-to-use solution, liquid	form powder	form ready-to-use solution, liquid	form -
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
concentration 100 mg/mL in DMSO	concentration -	concentration 25 mg/mL in DMSO	concentration -
color colorless to faint yellow	color white to beige	color colorless to faint yellow	color -

Still not finding the right product?

Explore all of our products under Cotrimoxazole

Pictograms

GHS08

Signal Word

Warning

Hazard Codes

H361fd,H412

Precautionary Statements

P202 - P273 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Aquatic Chronic 3 - Repr. 2

Storage Class

12 - Non Combustible Liquids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.