A143

(S)-(−)-Atenolol

powder

• Synonym(s): (−)-4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzeneacetamide
• Linear Formula: (CH₃)₂CHNHCH₂CH(OH)CH₂OC₆H₄CH₂CONH₂
• CAS Number: 93379-54-5
• Molecular Weight: 266.34
• NACRES: NA.77
• PubChem Substance ID: 24277807
• UNSPSC Code: 12352200
• MDL number: MFCD00074918
• Form: powder

Properties

• form: powder
• Quality Segment: 100
• optical activity: [α]23/D −10.5°, c = 0.5 in H₂O(lit.)
• color: white to beige
• mp: 148-152 °C (lit.)
• solubility: 0.1 M HCl: soluble
• SMILES string: CC(C)NC[C@H](O)COc1ccc(CC(N)=O)cc1
• InChI: 1S/C14H22N2O3/c1-10(2)16-8-12(17)9-19-13-5-3-11(4-6-13)7-14(15)18/h3-6,10,12,16-17H,7-9H2,1-2H3,(H2,15,18)/t12-/m0/s1
• InChI key: METKIMKYRPQLGS-LBPRGKRZSA-N
• Gene Information: human ... ADRB1(153)

Description

Application

(S)-(-)-Atenolol may be used as a standard in the preparation of enantiomer for high-performance liquid chromatography-tandem mass spectrometry studies (HPLC-MS/MS).[1] It has also been used in the β blocking molecule for Raman spectroscopy studies.

Biochem/physiol Actions

(S)-(-)-Atenolol is a β1-adrenergic receptor antagonist and an active enantiomer of atenolol.[1]

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)