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A0606

Sigma-Aldrich

Aurothioglucose hydrate

≥96% (titration)

Synonym(s):

Gold thioglucose, Solganal, Solganol

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About This Item

Empirical Formula (Hill Notation):
C6H11AuO5S · xH2O
CAS Number:
12192-57-3
Molecular Weight:
392.18 (anhydrous basis)
EC Number:
235-365-7
UNSPSC Code:
12352200
PubChem Substance ID:
24724383
NACRES:
NA.77

Assay

≥96% (titration)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 5 mg/mL, clear

storage temp.

2-8°C

SMILES string

O.OC[C@H]1O[C@H](S[Au])[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C6H12O5S.Au.H2O/c7-1-2-3(8)4(9)5(10)6(12)11-2;;/h2-10,12H,1H2;;1H2/q;+1;/p-1/t2-,3-,4+,5-,6-;;/m1../s1

InChI key

SGVIEHTYEMEDRR-PKXGBZFFSA-M

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Application

Aurothioglucose hydrate has been used in redox stress survival assay in human cell lines and for inducing obese phenotype in mice.

Biochem/physiol Actions

Aurothioglucose, a gold compound used clinically to treat rheumatoid arthritis, has recently been found to be a potent PKCiota-Par6 interaction inhibitor, with an IC50 approximately 1 μM. Disruption of this interaction disrupts a rac1 signaling pathway that is required for transformed growth in non-small-cell lung cancer.

Features and Benefits

This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H317,H334

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Development of chrysiasis after Q-switched ruby laser treatment of solar lentigines.
David E Geist et al.
Journal of the American Academy of Dermatology, 55(2 Suppl), S59-S60 (2006-07-18)
Morgan L Locy et al.
Antioxidants & redox signaling, 17(10), 1407-1416 (2012-05-23)
Pulmonary oxygen toxicity contributes to lung injury in newborn and adult humans. We previously reported that thioredoxin reductase (TrxR1) inhibition with aurothioglucose (ATG) attenuates hyperoxic lung injury in adult mice. The present studies tested the hypothesis that TrxR1 inhibition protects
Yukiko Miyamoto et al.
Journal of medicinal chemistry, 64(10), 6608-6620 (2021-05-12)
Trichomonas vaginalis causes the most common, nonviral sexually transmitted infection. Only metronidazole (Mz) and tinidazole are approved for treating trichomoniasis, yet resistance is a clinical problem. The gold(I) complex, auranofin, is active against T. vaginalis and other protozoa but has
M D Levin et al.
The Netherlands journal of medicine, 61(6), 223-225 (2003-09-19)
Thrombocytopenia is a well-known side effect following intramuscular gold therapy in patients with rheumatoid arthritis. Thrombocytopenia may occur at any time and it can be irreversible and sometimes fatal despite cytotoxic or immunosuppressive therapy. We describe two patients who presented
Gabriela Maggioli et al.
The Journal of parasitology, 90(2), 205-211 (2004-05-29)
Thioredoxin reductase (TrxR), an enzyme belonging to the flavoprotein family of pyridine nucleotide-disulfide oxidoreductases, was isolated from the deoxycholate-soluble extract of the common liver fluke, Fasciola hepatica. Purification to homogeneity of the 60-kDa enzyme from the adult worm was achieved
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Protein kinase C (PKC) is an AGC kinase that phosphorylates serine and threonine residues in many target proteins.

Protein Kinase C (PKC)

Protein kinase C (PKC) is an AGC kinase that phosphorylates serine and threonine residues in many target proteins.

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