81275

Poly(ethylene glycol)

tested according to Ph. Eur., 20,000

• Synonym(s): Macrogol 20,000, Polyethylene glycol, Polyoxyethylene, PEG
• Linear Formula: H(OCH₂CH₂)_nOH
• CAS Number: 25322-68-3
• MDL number: MFCD00081839
• UNSPSC Code: 12161900
• PubChem Substance ID: 24887731
• NACRES: NA.21

Properties

• Agency: tested according to Ph. Eur.
• Quality Level: 100
• form: flakes
• mol wt: 16000-24000
• application(s): pharmaceutical (small molecule)
• SMILES string: C(CO)O
• InChI: 1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2
• InChI key: LYCAIKOWRPUZTN-UHFFFAOYSA-N

Description

General description

Polyethylene glycol (PEG) is a versatile and non-ionic polymer[1] commonly used in a range of industrial and pharmaceutical applications due to its low toxicity, hydrophobic nature, and semicrystalline structure. It is made up of CH₂-CH₂O repeating units and its ability to exist in both monomer and aqueous phases at high temperatures[2] makes it valuable for a range of research applications.

Application

• Novel fibrous Ag(NP) decorated clay-polymer composite: Implications in water purification contaminated with predominant micro-pollutants and bacteria: This study demonstrates the use of poly(ethylene glycol) (PEG) for the creation of novel fibrous clay-polymer composites, enhancing the removal efficiency of micro-pollutants and bacteria in water treatment systems (Goswami et al., 2024).


• Striving for Uniformity: A Review on Advances and Challenges To Achieve Uniform Polyethylene Glycol: This review addresses the advances in the uniform production of poly(ethylene glycol) (PEG), critical for its application in drug delivery and pharmaceutical formulations, discussing the material′s solubility, biocompatibility, and stabilization properties (Bento et al., 2024).


• Assessing the structural stability and drug encapsulation efficiency of poly(ethylene glycol)-poly(L-lactic acid) nanoparticles loaded with atorvastatin calcium: The study evaluates the use of PEG in polymeric nanoparticles, focusing on optimizing drug encapsulation efficiency and stability, which is pivotal for effective drug delivery systems (Feng et al., 2024).


• Design and Evaluation of Nanoscale Materials with Programmed Responsivity towards Epigenetic Enzymes: This research explores the role of PEG in designing responsive nanoscale materials aimed at targeting epigenetic enzymes, showcasing PEG′s versatility in enhancing pharmaceutical applications (Ray et al., 2024).


• Membranes composed of poly(lactic acid)/poly(ethylene glycol) and Ora-pro-nóbis (Pereskia aculeata Miller) extract for dressing applications: This article highlights the application of PEG in developing biocompatible and efficient wound dressing materials, combining poly(lactic acid) and natural extracts to enhance healing processes (Mendes et al., 2024).

Biochem/physiol Actions

Polyethylene glycols (PEGs) or macrogols are broadly used as additives in cosmetics and pharmaceuticals.[3] Addition of this hydrophilic polymer blocks and reverses some types of surfactant inactivation in vitro.[1] PEG can be used as a macroinitiator, stabilizer, or dispersant in the field of emulsion polymerization with the help of its derivatives or modifications.[2]

Features and Benefits

• Environment friendly[2]
• Biocompatible[2]
• Unique solvent solution[2]

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): 281.5 °F - closed cup
• Flash Point(C): 138.6 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves